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Short Report: HMS-Related Hemolysis after Acute Attacks of Plasmodium vivax Malaria

October 10, 2011 - 08:36 -- Patrick Sampao
Oriol Mitjà, Russell Hays, James Malken, Anthony Ipai, Samson Kangapu, Jenny Robson and Quique Bassat
Am J Trop Med Hyg 2011 85:616-618

MalariaWorldAmong a cohort of 1,213 cases treated for Plasmodium vivax malaria from an isolated Papua New Guinean population, seven adults with severe and sustained hemolytic anemia after clearance of the peripheral parasitemia were prospectively investigated.

In Tanzania, Hemolysis after a Single Dose of Primaquine Coadministered with an Artemisinin Is Not Restricted to Glucose-6-Phosphate Dehydrogenase-Deficient (G6PD A–) Individuals

April 20, 2010 - 08:52 -- Kabogo Ndegwa
Seif A. Shekalaghe, Roel ter Braak, Teun Bousema,.et al
Antimicrobial Agents and Chemotherapy, May 2010, p. 1762-1768, Vol. 54, No. 5

The current interest in malaria elimination has led to a renewed interest in drugs that can be used for mass administration to minimize malaria transmission. Primaquine (PQ) is the only generally available drug with a strong activity against mature Plasmodium falciparum gametocytes, the parasite stage responsible for transmission.

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Open Access | Hemolysis Is Associated with Low Reticulocyte Production Index and Predicts Blood Transfusion in Severe Malarial Anemia

April 8, 2010 - 13:04 -- Kabogo Ndegwa
Rolf Fendel, Christian Brandts, Annika Rudat, Andrea Kreidenweiss, Claudia Steur, Iris Appelmann, Bettina Ruehe, Paul Schröder, Wolfgang E. Berdel, Peter G. Kremsner, Benjamin Mordmüller
PLoS ONE 5(4): e10038.

In Gabon, Central Africa, one out of four inpatients have severe malarial anemia (SMA), a life-threatening complication if left untreated. Our results show the multifactorial pathophysiology of SMA, whereby EVH and IVH play a particularly important role. 

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