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multi drug resistance

Elimination of Plasmodium falciparum in an area of multi-drug resistance

August 17, 2015 - 08:29 -- Open Access
Author(s): 
Khin Lwin, Mallika Imwong, Preyanan Suangkanarat, Atthanee Jeeyapant, Benchawan Vihokhern, Klanarong Wongsaen, Georges Snounou, Lilly Keereecharoen, Nicholas J White, Francois Nosten
Reference: 
Malaria Journal 2015, 14:319 (16 August 2015)

Mass drug administration with dihydroartemisinin-piperaquine may be an effective strategy to eliminate P. falciparum rapidly where multi-drug resistance is present.

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Surveillance of artemether-lumefantrine associated Plasmodium falciparum multidrug resistance protein-1 gene polymorphisms in Tanzania

July 22, 2014 - 09:01 -- Open Access
Author(s): 
Kavishe RA, Paulo P, Kaaya RD, Kalinga A, van Zwetselaar M, Chilongola J, Roper C, Alifrangis M
Reference: 
Malaria Journal 2014, 13 :264 (9 July 2014)

This is the first country-wide survey on Pfmdr1 mutations associated with ACT resistance. Distribution

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Open Access | Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai-Myanmar border

October 13, 2010 - 09:19 -- Kabogo Ndegwa
Author(s): 
Na-Bangchang K, Ruengweerayut R, Mahamad P, Ruengweerayut K, Chaijaroenkul W
Reference: 
Malaria Journal 2010, 9:273 (8 October 2010)

Although pharmacokinetic (ethnic-related) factors including resistance of P. falciparum to mefloquine contribute to some treatment failure following treatment with a three-day combination regimen of artesunate-mefloquine, results suggest that artesunate resistance may be emerging at the Thai-Myanmar border.

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Multiple Genetic Backgrounds of the Amplified Plasmodium falciparum Multidrug Resistance (pfmdr1) Gene and Selective Sweep of 184F Mutation in Cambodia

April 8, 2010 - 07:58 -- Kabogo Ndegwa
Author(s): 
S Vinayak, MT Alam, R Sem, NK Shah, AI Susanti, P Lim, S Muth, JD Maguire, WO Rogers, T Fandeur, JW Barnwell, AA Escalante, C Wongsrichanalai, F Ariey, SR Meshnick, V Udhayakumar
Reference: 
The Journal of Infectious Diseases 2010;201

The emergence of artesunate‐mefloquine (AS+MQ)–resistant Plasmodium falciparum in the Thailand‐Cambodia region is a major concern for malaria control.

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