Mass drug administration with dihydroartemisinin-piperaquine may be an effective strategy to eliminate P. falciparum rapidly where multi-drug resistance is present.
multi drug resistance
This is the first country-wide survey on Pfmdr1 mutations associated with ACT resistance. Distribution
Although pharmacokinetic (ethnic-related) factors including resistance of P. falciparum to mefloquine contribute to some treatment failure following treatment with a three-day combination regimen of artesunate-mefloquine, results suggest that artesunate resistance may be emerging at the Thai-Myanmar border.
The emergence of artesunate‐mefloquine (AS+MQ)–resistant Plasmodium falciparum in the Thailand‐Cambodia region is a major concern for malaria control.