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First attempt to validate the gSG6-P1 salivary peptide as an immuno-epidemiological tool for evaluating human exposure to Anopheles funestus bites

September 16, 2010 - 08:06 -- Kabogo Ndegwa
Anne Poinsignon, Badara Samb, Franck Remoue, et al
Tropical Medicine & International Health, Volume 15, Issue10, Pages 1198 – 1203, October 2010

The results suggest that the evaluation of the IgG response specific to gSG6-P1 in children could also represent a biomarker of exposure to An. funestus bites. The availability of such a biomarker evaluating the exposure to both main Plasmodium falciparum vectors in Africa could be particularly relevant as a direct criterion for the evaluation of the efficacy of vector control strategies.

Open Access | Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes

April 9, 2010 - 12:44 -- Kabogo Ndegwa
A Rennenberg, C Lehmann, A Heitmann, T Witt, G Hansen, K Nagarajan, C Deschermeier, V Turk, R Hilgenfeld, VT Heussler
PLoS Pathog (2010) 6: e1000825.

Plasmodium parasites must control cysteine protease activity that is critical for hepatocyte invasion by sporozoites, liver stage development, host cell survival and merozoite liberation.

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