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Open Access | A Genetic Screen for Attenuated Growth Identifies Genes Crucial for Intraerythrocytic Development of Plasmodium falciparum

October 18, 2010 - 07:39 -- Patrick Sampao
Bharath Balu, Naresh Singh, Steven P. Maher, John H. Adams
PLoS ONE 5(10): e13282.

This study demonstrates the feasibility of much needed forward genetics approaches for P. falciparum to better characterize its genome and accelerate drug and vaccine development.


Short Communication: Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria

September 20, 2010 - 13:53 -- Patrick Sampao
Bianor Valente, Paulo A. Campos, Virgílio E. do Rosário, Henrique Silveira
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 10, October 2010, Pages 687-689

The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy.

Review: Detecting signatures of balancing selection to identify targets of anti-parasite immunity

June 29, 2010 - 08:33 -- Patrick Sampao
Gareth D. Weedall, David J. Conway
Trends in Parasitology, Volume 26, Issue 7, July 2010, Pages 363-369

We focus on malaria parasites to illustrate challenges and opportunities for detecting targets of frequency-dependent immune selection to discover new potential vaccine candidates.

Medical Condition: 

Open Access | A Systems-Based Analysis of Plasmodium vivax Lifecycle Transcription from Human to Mosquito

April 7, 2010 - 12:16 -- Kabogo Ndegwa
Scott J. Westenberger, Colleen M. McClean, Rana Chattopadhyay, Neekesh V. Dharia, Jane M. Carlton, John W. Barnwell, William E. Collins, Stephen L. Hoffman, Yingyao Zhou, Joseph M. Vinetz, Elizabeth A. Winzeler
PLoS Negl Trop Dis 4(4): e653


To overcome the barriers to traditional molecular biology in P. vivax, we examined parasite transcriptional changes in samples from infected patients and mosquitoes in order to characterize gene function, define regulatory sequences and reveal new potential vaccine candidate genes.

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