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clinical malaria

Fc Gamma Receptor IIIB (FcγRIIIB) Polymorphisms Are Associated with Clinical Malaria in Ghanaian Children

October 2, 2012 - 08:05 -- Kabogo Ndegwa
Author(s): 
Bright Adu, Daniel Dodoo, Selorme Adukpo, Paula L. Hedley, Fareed K. N. Arthur, Thomas A. Gerds, Severin O. Larsen, Michael Christiansen, Michael Theisen
Reference: 
PLoS ONE 7(9): e46197

MalariaWorldPlasmodium falciparum malaria kills nearly a million people annually. Over 90% of these deaths occur in children under five years of age in sub-Saharan Africa.

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Not Open Access | Source of Clinical Malaria in Mixed-Species Infections

July 25, 2012 - 15:40 -- Patrick Sampao
Author(s): 
Miles B. Markus
Reference: 
Journal of Travel Medicine, Volume 19, Issue 4, page 275, July 2012

MalariaWorldMenner and colleagues reported on an interesting case of the development of symptomatic Plasmodium falciparum malaria following treatment for Plasmodium ovale malaria.

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HIV-1 Protease Inhibitors and Clinical Malaria: a Secondary Analysis of the AIDS Clinical Trials Group A5208 Study

January 24, 2012 - 13:06 -- Kabogo Ndegwa
Author(s): 
Kimberly A. Porter, Stephen R. Cole, Steven R. Meshnick, et al.
Reference: 
Antimicrob. Agents Chemother. February 2012 vol. 56 no. 2 995-1000

MalariaWorldHIV-1 protease inhibitors (PIs) have antimalarial activity in vitro and in murine models. The potential beneficial effect of HIV-1 PIs on malaria has not been studied in clinical settings.

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Open Access | To assess whether indoor residual spraying can provide additional protection against clinical malaria over current best practice of long-lasting insecticidal mosquito nets in The Gambia: study protocol for a two-armed cluster-randomised tria

June 14, 2011 - 13:54 -- Patrick Sampao
Author(s): 
Margaret Pinder, Musa Jawara, Lamin BS Jarju, Balla Kandeh, David Jeffries, Manuel F Lluberas, Kalifa Bojang, David J Conway and Steve W Lindsay
Reference: 
Trials 2011, 12:147, 10 June 2011

Exposure to malaria parasites will be assessed using light and exit traps followed by detection of Anopheles gambiae species and sporozoite infection. Study children will be surveyed at the end of each transmission season to estimate the prevalence of Plasmodium falciparum infection and the prevalence of anaemia.

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Open Access | Antibody levels to multiple malaria vaccine candidate antigens in relation to clinical malaria episodes in children in the Kasena-Nankana district of Northern Ghana

May 5, 2011 - 07:16 -- Kabogo Ndegwa
Author(s): 
Daniel Dodoo, Frank Atuguba, Samuel Bosomprah, Nana Akosua Ansah, Patrick Ansah, Helena Lamptey, Beverly Egyir, Abraham R Oduro, Ben Gyan, Abraham Hodgson, Kwadwo A Koram
Reference: 
Malaria Journal 2011, 10:108 (1 May 2011)

The data from this study support the view that a multivalent vaccine involving different antigens is most likely to be more effective than a monovalent one.

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Cellular Immunilogy and Immune Regulation: Cross-Talk between T Cells and NK Cells Generates Rapid Effector Responses to Plasmodium falciparum-Infected Erythrocytes

May 19, 2010 - 09:17 -- Kabogo Ndegwa
Author(s): 
Amir Horowitz, Kirsty C. Newman, J. Henry Evans, Daniel S. Korbel, Daniel M. Davis, and Eleanor M. Riley
Reference: 
The Journal of Immunology, 2010, 184, 6043 -6052

Rapid cell-mediated immune responses, characterized by production of proinflammatory cytokines, such as IFN-{gamma}, can inhibit intraerythrocytic replication of malaria parasites and thereby prevent onset of clinical malaria.

Review: Suppression of vaccine responses by malaria: insignificant or overlooked?

April 13, 2010 - 14:14 -- Kabogo Ndegwa
Author(s): 
Aubrey J Cunnington, Eleanor M Riley
Reference: 
Expert Rev Vaccines April 2010, Vol. 9, No. 4, Pages 409-429

Malaria is widely reported to suppress immune responses to heterologous antigens, including vaccines, but the evidence base for this assumption is patchy and confusing.

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Open Access | Intermittent preventive treatment in infants for the prevention of malaria in rural Western Kenya: a randomized, double-blind placebo-controlled trial

April 8, 2010 - 07:00 -- Kabogo Ndegwa
Author(s): 
FO Odhiambo, MJ Hamel, J Williamson, K Lindblade, FO ter Kuile, E Peterson, P Otieno, S Kariuki, J Vulule, L Slutsker, RD Newman
Reference: 
PLoS One (2010) 5: e10016.

IPTi with long-acting regimens provide protection against clinical malaria for up to 8 weeks even in the presence of high ITN coverage, and that the prophylactic rather than the treatment effect of IPTi appears central to its protective efficacy.

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