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Short Communication: Natural frequency of polymorphisms linked to the chondroitin 4-sulfotransferase genes and its association with placental malaria

September 20, 2010 - 13:53 -- Patrick Sampao
Bianor Valente, Paulo A. Campos, Virgílio E. do Rosário, Henrique Silveira
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 10, October 2010, Pages 687-689

The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy.

Open Access | The Survival Strategies of Malaria Parasite in the Red Blood Cell and Host Cell Polymorphisms

August 25, 2010 - 15:09 -- Patrick Sampao
Gunanidhi Dhangadamajhi, Shantanu Kumar Kar, and Manoranjan Ranjit
Malaria Research and Treatment, Volume 2010 (2010)

The current paper focuses on interactions between the Plasmodium parasite and its metabolically highly reduced host cell, the natural selection of numerous polymorphisms in the genes encoding hemoglobin and other erythrocyte proteins.

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Open Access | Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection

June 14, 2010 - 13:00 -- Kabogo Ndegwa
Horton AA, Lee Y, Coulibaly CA, Rashbrook VK, Cornel AJ, Lanzaro GC, Luckhart S
Malaria Journal 2010, 9:160 (11 June 2010)

Seven of these eight infection-associated and linked SNPs alter codon frequency or introduce non-synonymous changes that would be predicted to alter protein structure and, hence, function, suggesting that these SNPs could alter immune signaling and responsiveness to parasite infection.

Genetic association of Toll-like-receptor 4 and tumor necrosis factor-α polymorphisms with Plasmodium falciparum blood infection levels

May 27, 2010 - 15:05 -- Patrick Sampao
Madhumita B., Ardhendu K. M., et al.
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 686-696

Association of parasite load with genotypes was examined using model based and model free approaches.

Association of Microsatellite Variations of Plasmodium falciparum Na+/H+ Exchanger (Pfnhe-1) Gene with Reduced In Vitro Susceptibility to Quinine: Lack of Confirmation in Clinical Isolates from Africa

May 4, 2010 - 13:56 -- Patrick Sampao
Valérie Andriantsoanirina, Didier Ménard, Stéphane Rabearimanana, Véronique Hubert, Christiane Bouchier, Magali Tichit, Jacques Le Bras, and Rémy Durand
Am J Trop Med Hyg, May 2010; 82: 782 - 787.

We concluded that the studied polymorphisms in Pfnhe-1 did not appear as valid molecular markers of in vitro susceptibility to quinine in P. falciparum isolates from Africa.

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Mechanisms of Resistance: Selection of Known Plasmodium falciparum Resistance-Mediating Polymorphisms by Artemether-Lumefantrine and Amodiaquine- Sulfadoxine-Pyrimethamine but Not Dihydroartemisinin- Piperaquine in Burkina Faso

April 20, 2010 - 09:01 -- Kabogo Ndegwa
Anyirékun Fabrice Somé, Yves Y. Séré, Christian Dokomajilar, Issaka Zongo, Noël Rouamba, Bryan Greenhouse, Jean-Bosco Ouédraogo, and Philip J. Rosenthal
Antimicrobial Agents and Chemotherapy, May 2010, p. 1949-1954, Vol. 54, No. 5

Artemether-lumefantrine (AL), dihydroartemisinin-piperaquine (DP), and amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) offer excellent antimalarial efficacy but may select for parasite polymorphisms that decrease drug sensitivity. We evaluated the selection of known polymorphisms in genes encoding putative transporters (pfcrt and pfmdr1) and SP targets (pfdhfr and pfdhps) in parasites that caused new infections within 42 days of therapy for uncomplicated falciparum malaria in Burkina Faso.

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