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malarial

Open Access | Engineering the Chloroplast Targeted Malarial Vaccine Antigens in Chlamydomonas Starch Granules

December 16, 2010 - 12:07 -- Kabogo Ndegwa
Author(s): 
David Dauvillée, Stéphane Delhaye, Sébastien Gruyer, Christian Slomianny, Samuel E. Moretz, Christophe d'Hulst, Carole A. Long, Steven G. Ball, Stanislas Tomavo
Reference: 
PLoS ONE 5(12): e15424

This novel system paves the way for the production of clinically relevant plasmodial antigens as algal starch-based particles designated herein as amylosomes, demonstrating that efficient production of edible vaccines can be genetically produced in Chlamydomonas.

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Transgenic Plasmodium that expresses HIV-1 Gag elicits immunity and protects mice against vaccinia virus-gag and malarial parasites

November 23, 2010 - 09:54 -- Patrick Sampao
Author(s): 
Bo Jiang, Li Qin, Yanhua Du, Nanzheng Peng, Ling Chen, Zhiwei Chen, Xiaoping Chen
Reference: 
Vaccine, Volume 28, Issue 50, 23 November 2010, Pages 7915-7922

We demonstrated a novel vaccination strategy that uses a live transgenic protozoan parasite-based bivalent vaccine to immunize mice and confer significant levels of protection against VV-gag and malarial parasite challenges.

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Host Response and Inflamation: Involvement of Inflammatory Chemokines in Survival of Human Monocytes Fed with Malarial Pigment

October 22, 2010 - 12:43 -- Patrick Sampao
Author(s): 
Giuliana G., Mauro P., et al.
Reference: 
Infect. Immun., Nov 2010; 78: 4912 - 4921.

The aim of the present study was to clarify the role of HZ in cell survival, focusing on the qualitative and temporal expression patterns of proinflammatory and antiapoptotic molecules.

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Immunogenicity and protective efficacy of a recombinant yellow fever vaccine against the murine malarial parasite Plasmodium yoelii

June 14, 2010 - 13:06 -- Patrick Sampao
Author(s): 
Cristina T., Silvia B., et al.
Reference: 
Vaccine, Volume 28, Issue 29, 23 June 2010, Pages 4644-4652

Taken together, these results show that recombinant YF17D can efficiently express CSP in culture, and prime a protective immune response in vivo.

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Clinical Picture: Malarial retinopathy and fluorescein angiography findings in a Malawian child with cerebral malaria

May 25, 2010 - 13:18 -- Patrick Sampao
Author(s): 
Simon J Glover, Richard J Maude, Terrie E Taylor, Malcolm E Molyneux, Nicholas AV Beare
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 6, June 2010, Page 440

No abstract available

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Open Access | Local scale prediction of Plasmodium falciparum malaria transmission in an endemic region using temperature and rainfall

December 24, 2009 - 14:07 -- Ingeborg van Schayk
Author(s): 
Yazoume´ Ye´ 1*, Moshe Hoshen2, Catherine Kyobutungi1, Vale´ rie R. Louis3 and Rainer Sauerborn4,3
Reference: 
Global Health Action 2009

We develop, fit and validate a non-spatial dynamic model driven by meteorological conditions that can capture seasonal malaria transmission dynamics at the village level in a malaria holoendemic area of north-western Burkina Faso.

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Mechanisms of malarial anaemia: Potential involvement of the Plasmodium falciparum low molecular weight rhoptry-associated proteins

October 31, 2009 - 09:51 -- Ingeborg van Schayk
Author(s): 
Nancy W. Awah, Marita Troye-Blomberg, Klavs Berzins, Jürg Gysin
Reference: 
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 295-302

In this study we further investigated the mechanisms mediating the destruction of nEs in the development of severe malarial anaemia and the possible involvement of RAP-2/RSP-2 and other members of the low molecular weight rhoptry complex (RAP-1: rhoptry-associated protein-1 and RAP-3: rhoptry-associated protein-3).

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