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Open Access | Heritability of the Human Infectious Reservoir of Malaria Parasites

July 2, 2010 - 11:11 -- Kabogo Ndegwa
Author(s): 
Yaye Ramatoulaye Lawaly, Anavaj Sakuntabhai, Rick Paul, et al
Reference: 
PLoS ONE 5(6): e11358

The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics.

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Open Access | Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors for the Cerebral Malaria Syndrome in Angolan Children

June 18, 2010 - 11:23 -- Kabogo Ndegwa
Author(s): 
Maria Rosário Sambo, Maria Jesus Trovoada, Carla Benchimol, Vatúsia Quinhentos, Lígia Gonçalves, Rute Velosa, Maria Isabel Marques, Nuno Sepúlveda, Taane G. Clark, Stefan Mustafa, Oswald Wagner, António Coutinho, Carlos Penha-Gonçalves
Reference: 
PLoS ONE 5(6): e11141.

These results represent the first report on CM genetic risk factors in Angolan children and suggest the novel hypothesis that genetic variants of the TGFB2 and HMOX1 genes may contribute to confer a specific risk of developing the CM syndrome in patients with severe P. falciparum malaria.

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Open Access | Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection

June 14, 2010 - 13:00 -- Kabogo Ndegwa
Author(s): 
Horton AA, Lee Y, Coulibaly CA, Rashbrook VK, Cornel AJ, Lanzaro GC, Luckhart S
Reference: 
Malaria Journal 2010, 9:160 (11 June 2010)

Seven of these eight infection-associated and linked SNPs alter codon frequency or introduce non-synonymous changes that would be predicted to alter protein structure and, hence, function, suggesting that these SNPs could alter immune signaling and responsiveness to parasite infection.

Evidence for negative selection on the gene encoding rhoptry-associated protein 1 (RAP-1) in Plasmodium spp.

May 27, 2010 - 14:51 -- Patrick Sampao
Author(s): 
Elizabeth M. R., Amanda C. P., et al.
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 655-661

We investigated the genetic diversity of orthologous genes encoding the rhoptry-associated protein 1 (RAP-1), a low polymorphic protein of malarial parasites that is involved in erythrocyte invasion.

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Evolutionary insights into insecticide resistance gene families of Anopheles gambiae

May 27, 2010 - 11:42 -- Patrick Sampao
Author(s): 
Hemlata Srivastava, Meenu Sharma, Jyotsana Dixit, Aparup Das
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 5, July 2010, Pages 620-628

We herein utilized the whole genome sequence information of the malaria vector Anopheles gambiae and inferred evolutionary pattern of the three known IR gene families (CYP, GST and COE).

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Open Access | Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya

April 6, 2010 - 11:36 -- Ingeborg van Schayk
Author(s): 
Lyna Zhang, Donald Prather, Jodi Vanden Eng, Sara Crawford, Simon Kariuki, Feiko ter Kuile, Dianne Terlouw, Bernard Nahlen, Altaf A Lal, Laurence Slutsker, Venkatachalam Udhaykumar, Ya Ping Shi
Reference: 
Malaria Journal 2010, 9:87 (29 March 2010)

This study has shown strong associations between polymorphisms in the genes of IL12A and IL12RB1 and protection from SMA in Kenyan children, suggesting that human genetic variants of IL12 related genes may significantly contribute to the development of anaemia in malaria patients.

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