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severe malarial anaemia

Open Access | Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya

April 6, 2010 - 11:36 -- Ingeborg van Schayk
Author(s): 
Lyna Zhang, Donald Prather, Jodi Vanden Eng, Sara Crawford, Simon Kariuki, Feiko ter Kuile, Dianne Terlouw, Bernard Nahlen, Altaf A Lal, Laurence Slutsker, Venkatachalam Udhaykumar, Ya Ping Shi
Reference: 
Malaria Journal 2010, 9:87 (29 March 2010)

This study has shown strong associations between polymorphisms in the genes of IL12A and IL12RB1 and protection from SMA in Kenyan children, suggesting that human genetic variants of IL12 related genes may significantly contribute to the development of anaemia in malaria patients.

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