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Plasmodium falciaprum

Efficacy and safety of dihydroartemisinin–piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial

August 27, 2019 - 21:39 -- Open Access
Esperança Sevene, Clifford G. Banda, Victor Mwapasa, et al.
Malaria Journal 2019 18:277, 20 August 2019

HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efficacy and safety has not been evaluated in HIV-infected individuals on ART, among whom drug–drug interactions are expected. Day-42 adequate clinical and parasitological response (ACPR) and incidence of adverse events were assessed in HIV-infected individuals on non-nucleoside reverse transcriptase inhibitor-based ART (efavirenz and nevirapine) with uncomplicated P. falciparum malaria treated with dihydroartemisinin–piperaquine.

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Computational prediction of protein interactions related to the invasion of erythrocytes by malarial parasites

December 2, 2014 - 16:06 -- Open Access
Xuewu Liu, Yuxiao Huang, Jiao Liang, Shuai Zhang, Yinghui Li, Jun Wang, Yan Shen, Zhikai Xu and Ya Zhao
BMC Bioinformatics 2014, 15:393

In this study, an expectation maximization algorithm was used to estimate the probabilities of domain-domain interactions (DDIs). Estimates of DDI probabilities were then used to infer PPI probabilities.

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Synthesis and structure–activity relationships of antimalarial 4-oxo-3-carboxyl quinolones

April 7, 2010 - 11:14 -- Kabogo Ndegwa
Yiqun Zhang, W. Armand Guiguemde, Martina Sigal, Fangyi Zhu, Michele C. Connelly, Solomon Nwaka, R. Kiplin Guy
Bioorganic & Medicinal Chemistry, Volume 18, Issue 7, 1 April 2010, Pages 2756-2766

The increasing prevalence of multi-drug-resistant Plasmodium falciparum drives the ongoing need for the development of new antimalarial drugs.

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Transfusion Practice: Efficacy and safety of exchange transfusion as an adjunct therapy for severe Plasmodium falciparum malaria in nonimmune travelers: a 10-year single-center experience with a standardized treatment protocol

March 31, 2010 - 12:19 -- Patrick Sampao
Perry J.J. van Genderen, Dennis A. Hesselink, Jacob M. Bezemer, Pieter J. Wismans, David Overbosch
Transfusion, Volume 50, Issue 4, Date: April 2010, Pages: 787-794

Although exchange transfusion (ET) has been considered as a controversial adjunct therapy, we have not encountered any case fatality since ET was introduced as a standard adjunct therapy for patients with severe malaria.

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