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Not Open Access | PI(3)P-independent and -dependent pathways function together in a vacuolar translocation sequence to target malarial proteins to the host erythrocyte

October 1, 2012 - 17:14 -- Patrick Sampao
Author(s): 
Souvik Bhattacharjee, Kaye D. Speicher, Robert V. Stahelin, David W. Speicher, Kasturi Haldar
Reference: 
Molecular and Biochemical Parasitology, Volume 185, Issue 2, October 2012, Pages 106-113

MalariaWorldWe have previously shown that the R to A mutation in the HT motif, abrogates VTS binding to PI(3)P (Kd > 5 μM). We now show that remarkably, the R to A mutant is exported to the host erythrocyte, for both membrane and soluble reporters, although the efficiency of export is reduced to ∼30% of that seen with a complete VTS.

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Not Open Access | Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases

June 14, 2012 - 10:13 -- Patrick Sampao
Author(s): 
Diana Caridha, April K. Kathcart, Dayadevi Jirage, Norman C. Waters
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 13, 1 July 2010, Pages 3863-3867

MalariaWorldIn this study, we identified thiophene and benzene sulfonamides as potent inhibitors of Pfmrk, a Plasmodium falciparum CDK with sequence homology to human CDK7. Several of the compounds demonstrated inhibitor selectivity for CDK7 over CDK1, CDK2, and CDK6.

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Open Access | Review: Structure-Function of Falcipains: Malarial Cysteine Proteases

February 21, 2012 - 13:47 -- Patrick Sampao
Author(s): 
Kailash C. Pandey and Rajnikant Dixit
Reference: 
Journal of Tropical Medicine, Volume 2012 (2012)

MalariaWorldStructural and functional analysis of falcipains showed that they have unique domains including a refolding domain and a hemoglobin binding domain.

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Open Access | Automated and unsupervised detection of malarial parasites in microscopic images

December 16, 2011 - 13:29 -- Patrick Sampao
Author(s): 
Purwar Y, Shah SL, Clarke G, Almugairi A, Muehlenbachs A
Reference: 
Malaria Journal 2011, 10:364 (13 December 2011)

MalariaWorldThe focus of this study is to develop a robust, unsupervised and sensitive malaria screening technique with low material cost and one that has an advantage over other techniques in that it minimizes human reliance and is, therefore, more consistent in applying diagnostic criteria.

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Open Access | Review: Severe Malarial Anemia: Innate Immunity and Pathogenesis

November 21, 2011 - 14:56 -- Patrick Sampao
Author(s): 
Douglas J. Perkins, Tom Were, Gregory C. Davenport, Prakasha Kempaiah, James B. Hittner, John Michael Ong'echa
Reference: 
Int J Biol Sci 2011; 7:1427-1442

MalariaWorldAn improved understanding of the etiological basis of suppression of erythropoietic responses in children with SMA may offer the much needed therapeutic alternatives for control of this global disease burden.

Open Access | Detection of malarial byproduct hemozoin utilizing its unique scattering properties

June 14, 2011 - 14:48 -- Patrick Sampao
Author(s): 
Benjamin K. Wilson, Matthew R. Behrend, Matthew P. Horning, and Michael C. Hegg
Reference: 
Optics Express, Vol. 19, Issue 13, pp. 12190-12196 (2011)

A new detection method is proposed and demonstrated using dark-field in conjunction with cross-polarization imaging and spectroscopy. SNRs greater than 50:1 are achieved for hemozoin in fresh blood without the addition of stains or reagents. The potential of such a detection system is discussed.

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Overexpression, purification and assessment of cyclosporin binding of a family of cyclophilins and cyclophilin-like proteins of the human malarial parasite Plasmodium falciparum

June 13, 2011 - 14:14 -- Patrick Sampao
Author(s): 
Alejandro Marín-Menéndez, Angus Bell
Reference: 
Protein Expression and Purification, Volume 78, Issue 2, August 2011, Pages 225-234

Previously a pET vector conferring a C-terminal His6 tag was used for recombinant expression and purification of one member of the P. falciparum cyclophilin family in Escherichia coli. The approach here was to use an identical method to produce all of the other members of this family and thereby allow the most consistent functional comparisons.

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Open Access | Intracytoplasmic Hemozoin (Malarial Pigment) in a Case of Severe, Aparasitemic Plasmodium falciparum Malaria

April 4, 2011 - 13:41 -- Patrick Sampao
Author(s): 
Romualdo Grande AND Carla Boschetti
Reference: 
Am J Trop Med Hyg, Apr 2011; 84: 509.

A 17-year-old girl from Togo with a β-thalassemia maior was seen at an emergency department with high fever, coma, and severe anemia (Hb < 3 g/dL). No malaria parasites were found on thin film and thick smears in the first few days of the infection.

Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum

January 14, 2011 - 13:07 -- Patrick Sampao
Author(s): 
Subash Chandra Mohapatra., Hemandra Kumar Tiwari.,Shyam Singh Chauhan., et al.
Reference: 
Journal of Biological Inorganic Chemistry, Volume 15, Number 3, 373-385

Our results suggest that these two compounds have antimalarial activities, and the IC50 values (0.025–0.032 μg/ml) are similar to the IC50 value of the standard drug chloroquine used in the bioassay. Lineweaver–Burk plots for inhibition of plasmepsin II by LCu(CH3COO)2 and LCuCl2 show that the inhibition is competitive with respect to the substrate.

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