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Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal

November 23, 2010 - 08:11 -- Kabogo Ndegwa
Oleksii A. Skorokhod, Luisa Caione, Tiziana Marrocco, Giorgia Migliardi, Valentina Barrera, Paolo Arese, Wanda Piacibello, and Evelin Schwarzer
Blood, 18 November 2010, Vol. 116, No. 20, pp. 4328-4337

Severe malaria anemia is characterized by inhibited/altered erythropoiesis and presence of hemozoin-(HZ)-laden bone-marrow macrophages.

PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking

March 31, 2010 - 07:18 -- Kabogo Ndegwa
Ankush Vaid, Ravikant Ranjan, Wynand A. Smythe, Heinrich C. Hoppe, and Pushkar Sharma
Blood, 25 March 2010, Vol. 115, No. 12, pp. 2500-2507

Our present studies suggest that PfPI3K, a novel phosphatidylinositol-3-kinase (PI3K) in Plasmodium falciparum, is exported to the host erythrocyte by the parasite in an active form.

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