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protease

Characterization of the monomer–dimer equilibrium of recombinant histo-aspartic protease from Plasmodium falciparum

June 14, 2010 - 13:58 -- Patrick Sampao
Author(s): 
Huogen Xiao, Lee-Ann K. Briere, Stanley D. Dunn, Rickey Y. Yada
Reference: 
Molecular and Biochemical Parasitology, Volume 173, Issue 1, September 2010, Pages 17-24

The present study found that the recombinant Trx–tHAP fusion protein aggregated during purification which could be prevented through the addition of 0.2% CHAPS. Trx–tHAP fusion protein was processed into a mature form of tHAP (mtHAP) by both autoactivation, and activation with either enterokinase or plasmepsin II.

The host targeting motif in exported Plasmodium proteins is cleaved in the parasite endoplasmic reticulum

March 26, 2010 - 16:40 -- Kabogo Ndegwa
Author(s): 
Andrew R. Osborne, Kaye D. Speicher, Pamela A. Tamez, Souvik Bhattacharjee, David W. Speicher, Kasturi Haldar
Reference: 
Molecular and Biochemical Parasitology, Volume 171, Issue 1, May 2010, Pages 25-31

Here, we generate parasite lines expressing HT motif containing proteins that are localized to different compartments within the parasite or host cell.

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