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eukaryotes

Short Communication: Structure of Plasmodium falciparum ADP-ribosylation factor 1

November 9, 2010 - 09:30 -- Kabogo Ndegwa
Author(s): 
WJ Cook, CD Smith, O Senkovich, AA Holder, D Chattopadhyay
Reference: 
Acta Crystallographica, Volume 66, Part 11 (November 2010)

Vesicular trafficking may play a crucial role in the pathogenesis and survival of the malaria parasite. ADP-ribosylation factors (ARFs) are among the major components of vesicular trafficking pathways in eukaryotes.

Open Access | Plasmodium falciparum transcriptional CDK-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity

March 25, 2010 - 12:27 -- Ingeborg van Schayk
Author(s): 
Jean Halbert, Lawrence Ayong, Leila Equinet, Karine Le Roch, Mary Hardy, Dean Goldring, Luc Reininger, Norman Waters, Debopam Chakrabarti, and Christian Doerig
Reference: 
Eukaryot. Cell. published 19 March 2010, 10.1128/EC.00005-10

Here, we report the characterisation of Pfcrk-3 (P. falciparum CDK-related kinase 3, PlasmoDB identifier PFD0740w), an unusually large CDK-related protein whose kinase domain displays maximal homology to those CDKs which are, in other eukaryotes, involved in the control of transcription.

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