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Both Hemolytic Anemia and Malaria Parasite-Specific Factors Increase Susceptibility to Nontyphoidal Salmonella enterica Serovar Typhimurium Infection in Mice

March 21, 2010 - 11:14 -- Ingeborg van Schayk
Christelle M. Roux, Brian P. Butler, Jennifer Y. Chau, Tatiane A. Paixao, Kong Wai Cheung, Renato L. Santos, Shirley Luckhart, and Renee M. Tsolis
Infect. Immun. 2010;78 1520-1527

Here we established a model for oral Salmonella enterica serotype Typhimurium challenge in mice infected with Plasmodium yoelii nigeriensis. Collectively, studies establishing a mouse model for this coinfection suggest that multiple distinct malaria-induced immune defects contribute to increased susceptibility to S. Typhimurium.

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