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artemisinin resistance

Spontaneous Mutations in the Plasmodium falciparum Sarcoplasmic/ Endoplasmic Reticulum Ca2+-ATPase (PfATP6) Gene among Geographically Widespread Parasite Populations Unexposed to Artemisinin-Based Combination Therapies

December 28, 2010 - 10:09 -- Kabogo Ndegwa
Author(s): 
Kazuyuki Tanabe, Sedigheh Zakeri, Nirianne Marie Q. Palacpac, Manada Afsharpad, Milijaona Randrianarivelojosia, Akira Kaneko, Aung Swi Prue Marma, Toshihiro Horii, and Toshihiro Mita
Reference: 
Antimicrobial Agents and Chemotherapy, January 2011, p. 94-100, Vol. 55, No. 1

Recent reports on the decline of the efficacy of artemisinin-based combination therapies (ACTs) indicate a serious threat to malaria control.

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Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria Parasites

December 28, 2010 - 09:35 -- Kabogo Ndegwa
Author(s): 
Dorothee Beez, Cecilia P. Sanchez, Wilfred D. Stein, and Michael Lanzer
Reference: 
Antimicrobial Agents and Chemotherapy, January 2011, p. 50-55, Vol. 55, No. 1

The emergence of artemisinin-resistant Plasmodium falciparum malaria jeopardizes efforts to control this infectious disease.

Open Access | Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy

December 14, 2010 - 06:25 -- Kabogo Ndegwa
Author(s): 
Gama BE, Almeida-de-Oliveira NK, de Souza JM, Santos F, de Carvalho LJ, Melo YF, Rosenthal PJ, Daniel-Ribeiro CT, Ferreira-da-Cruz M
Reference: 
Malaria Journal 2010, 9:355 (8 December 2010)

Although some polymorphism in pfmdr1 and pfatpase6 were verified, no reported haplotypes in both genes that may mediate altered response to ACT was detected before the introduction of this therapy in Brazil.

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Open Access | Dose‐Dependent Risk of Neutropenia after 7‐Day Courses of Artesunate Monotherapy in Cambodian Patients with Acute Plasmodium falciparum Malaria

November 23, 2010 - 06:59 -- Kabogo Ndegwa
Author(s): 
Delia Bethell, Youry Se, Mark M. Fukuda, et al.
Reference: 
Clinical Infectious Diseases 15 December 2010, Vol. 51, No. 12:

Artesunate remains a crucial drug for the treatment of malaria, and determining optimal dosing regimens is vital to overcome emerging resistant parasite strains along the Thai‐Cambodian border.

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Investigations into the Role of the Plasmodium falciparum SERCA (PfATP6) L263E Mutation in Artemisinin Action and Resistance

August 18, 2010 - 12:52 -- Kabogo Ndegwa
Author(s): 
Stephanie Gaw Valderramos, Daniel Scanfeld, Anne-Catrin Uhlemann, David A. Fidock, and Sanjeev Krishna
Reference: 
Antimicrobial Agents and Chemotherapy, September 2010, p. 3842-3852, Vol. 54, No. 9

Artemisinin-based combination therapies (ACTs) are highly effective for the treatment of Plasmodium falciparum malaria, yet their sustained efficacy is threatened by the potential spread of parasite resistance.

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Brief Report: High Heritability of Malaria Parasite Clearance Rate Indicates a Genetic Basis for Artemisinin Resistance in Western Cambodia

April 9, 2010 - 17:52 -- Ingeborg van Schayk
Author(s): 
Tim J. C. Anderson, Shalini Nair, Standwell Nkhoma, Jeff T. Williams, Mallika Imwong, Poravuth Yi, Duong Socheat, Debashish Das, Kesinee Chotivanich, Nicholas P. J. Day, Nicholas J. White, and Arjen M. Dondorp
Reference: 
The Journal of Infectious Diseases 2010;201:1326–1330

In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population.

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Reviews: Artemisinin resistance: current status and scenarios for containment

March 18, 2010 - 13:31 -- Patrick Sampao
Author(s): 
Arjen M. Dondorp, Shunmay Yeung, Lisa White, Chea Nguon, Nicholas P.J. Day, Duong Socheat, Lorenz von Seidlein
Reference: 
Nature Reviews Microbiology 8 March 2010

Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P. falciparum malaria has emerged on the Cambodia–Thailand border.

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