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artemisinin resistance

Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China-Myanmar border in 2007-2012

April 21, 2015 - 13:45 -- Open Access
Author(s): 
Zenglei Wang, Sony Shrestha, Xiaolian Li, Jun Miao, Lili Yuan, Mynthia Cabrera, Caitlin Grube, Zhaoqing Yang, Liwang Cui
Reference: 
Malaria Journal 2015, 14:168 (18 April 2015)

This study documented the presence of mutations in the K13 gene in parasite populations from the China-Myanmar border.

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Improving uptake and use of malaria rapid diagnostic tests in the context of artemisinin drug resistance containment in eastern Myanmar: an evaluation of incentive schemes among informal private healthcare providers

March 10, 2015 - 13:25 -- Open Access
Author(s): 
Tin Aung, Christopher White, Dominic Montagu, Willi McFarland, Thaung Hlaing, Hnin Khin, Aung San, Christina Briegleb, Ingrid Chen, May Sudhinaraset
Reference: 
Malaria Journal 2015, 14:105 (6 March 2015)

Results show that training and quality supervision of informal private healthcare providers can result in improved demand for, and appropriate use of RDTs in drug resistance containment areas in eastern Myanmar.

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Status of potential PfATP6 molecular markers for artemisinin resistance in Suriname

September 13, 2012 - 13:26 -- Kabogo Ndegwa
Author(s): 
Adhin MR, Labadie-Bracho M, Vreden SG
Reference: 
Malaria Journal 2012, 11:322 (11 September 2012)

MalariaWorldAll investigated isolates before and after the adoption of the ACT-regimen and independent of endemic region harbored the wild-type genotype for the three investigated polymorphisms.

Artemisinin resistance containment project in Thailand. i: implementation of electronic-based malaria information system for early case detection and individual case management in provinces along the Thai-Cambodian border

August 2, 2012 - 08:51 -- Kabogo Ndegwa
Author(s): 
Khamsiriwatchara A, Sudathip P, Sawang S, Vijakadge S, Potithavoranan T, Sangvichean A, Satimai W, Delacollette C, Singhasivanon P, Lawpoolsri S, Kaewkungwal J
Reference: 
Malaria Journal 2012, 11:247 (29 July 2012)

MalariaWorldThe eMIS demonstrated that it could capture essential data from individual malaria cases at local operational units, while effectively being used for situation and trend analysis at upper-management levels.

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Open Access | Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator

November 15, 2011 - 07:21 -- Kabogo Ndegwa
Author(s): 
Flegg JA, Guerin PJ, White NJ, Stepniewska K
Reference: 
Malaria Journal 2011, 10:339 (10 November 2011)

MalariaWorldThe parasite clearance estimator provides a consistent, reliable and accurate method to estimate the lag phase and malaria parasite clearance rate.

Medical Treatment: 

Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum

October 26, 2011 - 14:01 -- Kabogo Ndegwa
Author(s): 
O’Brien, Connor; Henrich, Philipp P.; Passi, Neha; Fidock, David A.
Reference: 
Current Opinion in Infectious Diseases, December 2011 - Volume 24 - Issue 6 - p 570–577

MalariaWorldShould ACTs fail, no suitable alternatives exist as first-line treatments of P. falciparum malaria.

Open Access | Methodology: The parasite clearance curve

September 29, 2011 - 07:05 -- Kabogo Ndegwa
Author(s): 
N J White
Reference: 
Malaria Journal 2011, 10:278 (22 September 2011)

MalariaWorldParasite clearance rates are important measures of anti-malarial drug efficacy. They are particularly important in the assessment of artemisinin resistance.

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Open Access | Artesunate Dose Escalation for the Treatment of Uncomplicated Malaria in a Region of Reported Artemisinin Resistance: A Randomized Clinical Trial

May 30, 2011 - 08:28 -- Kabogo Ndegwa
Author(s): 
Delia Bethell, Youry Se, Mark M. Fukuda, et al.
Reference: 
PLoS ONE 6(5): e19283

There is no pharmacodynamic benefit of increasing the daily dose of AS (4mg/kg) currently recommended for short-course combination treatment of uncomplicated malaria, even in regions with emerging artemisinin resistance, as long as the partner drug retains high efficacy.

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Spontaneous Mutations in the Plasmodium falciparum Sarcoplasmic/ Endoplasmic Reticulum Ca2+-ATPase (PfATP6) Gene among Geographically Widespread Parasite Populations Unexposed to Artemisinin-Based Combination Therapies

December 28, 2010 - 10:09 -- Kabogo Ndegwa
Author(s): 
Kazuyuki Tanabe, Sedigheh Zakeri, Nirianne Marie Q. Palacpac, Manada Afsharpad, Milijaona Randrianarivelojosia, Akira Kaneko, Aung Swi Prue Marma, Toshihiro Horii, and Toshihiro Mita
Reference: 
Antimicrobial Agents and Chemotherapy, January 2011, p. 94-100, Vol. 55, No. 1

Recent reports on the decline of the efficacy of artemisinin-based combination therapies (ACTs) indicate a serious threat to malaria control.

Medical Treatment: 

Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria Parasites

December 28, 2010 - 09:35 -- Kabogo Ndegwa
Author(s): 
Dorothee Beez, Cecilia P. Sanchez, Wilfred D. Stein, and Michael Lanzer
Reference: 
Antimicrobial Agents and Chemotherapy, January 2011, p. 50-55, Vol. 55, No. 1

The emergence of artemisinin-resistant Plasmodium falciparum malaria jeopardizes efforts to control this infectious disease.

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