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artemisinin resistance

A systematic review on anti-malarial drug discovery and antiplasmodial potential of green synthesis mediated metal nanoparticles: overview, challenges and future perspectives

October 7, 2019 - 15:31 -- Open Access
Author(s): 
Loick P. Kojom Foko, Francois Eya’ane Meva, Carole E. Eboumbou Moukoko, Agnes A. Ntoumba, Marie I. Ngaha Njila, Philippe Belle Ebanda Kedi, Lawrence Ayong and Leopold G. Lehman
Reference: 
Malaria Journal 2019 18:337, 3 October 2019

The recent emergence in Southeast Asia of artemisinin resistance poses major threats to malaria control and elimination globally. Green nanotechnologies can constitute interesting tools for discovering anti-malarial medicines. This systematic review focused on the green synthesis of metal nanoparticles as potential source of new antiplasmodial drugs.

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Pairwise growth competitions identify relative fitness relationships among artemisinin resistant Plasmodium falciparum field isolates

September 3, 2019 - 15:25 -- Open Access
Author(s): 
Abigail R. Tirrell, Katelyn M. Vendrely, Michael T. Ferdig, et al.
Reference: 
Malaria Journal 2019 18:295, 28 August 2019

Competitive outcomes between co-infecting malaria parasite lines can reveal fitness disparities in blood stage growth. Blood stage fitness costs often accompany the evolution of drug resistance, with the expectation that relatively fitter parasites will be more likely to spread in populations. With the recent emergence of artemisinin resistance, it is important to understand the relative competitive fitness of the metabolically active asexual blood stage parasites. Genetically distinct drug resistant parasite clones with independently evolved sets of mutations are likely to vary in asexual proliferation rate, contributing to their chance of transmission to the mosquito vector.

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An improved nucleic acid extraction method from dried blood spots for amplification of Plasmodium falciparum kelch13 for detection of artemisinin resistance

June 11, 2019 - 14:40 -- Open Access
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Author(s): 
Kayvan Zainabadi, Myaing M. Nyunt and Christopher V. Plowe
Reference: 
Malaria Journal 2019 18:192, 11 June 2019

Mutational analysis of the Plasmodium falciparum kelch 13 (k13) gene is routinely performed to track the emergence and spread of artemisinin resistance. Surveillance of resistance markers has been impeded by the difficulty of extracting sufficient DNA from low parasite density infections common in low-transmission settings, such as Southeast Asia. This problem can be overcome by collecting large volumes of venous blood. Efficient methods for extracting and amplifying k13 from dried blood spots (DBS) would facilitate resistance surveillance.

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Structure–activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines

March 26, 2019 - 15:50 -- Open Access
Author(s): 
Andreas Masch, Abed Nasereddin, Conrad Kunick, et al.
Reference: 
Malaria Journal 2019 18:89, 21 March 2019

The attachment of alkylamino side chains leads to the improvement of antiplasmodial activity and aqueous solubility of selective PfGSK-inhibitors belonging to the class of 4-phenylthieno[2,3-b]pyridines.

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NOT Open Access | Inactivation of Plasmepsins 2 and 3 Sensitizes Plasmodium falciparum to the Antimalarial Drug Piperaquine

March 28, 2018 - 15:36 -- NOT Open Access
Author(s): 
Angana Mukherjee, Dominic Gagnon, Dyann F. Wirth and Dave Richard
Reference: 
Antimicrob. Agents Chemother. April 2018 vol. 62 no. 4 e02309-17

Dihydroartemisinin-piperaquine (DHA-PPQ), the current frontline artemisinin combination therapy used to treat Plasmodium falciparum malaria in multiple Southeast Asian countries, is now increasingly failing in Cambodia, where artemisinin resistance is nearly fixed, which suggests that PPQ resistance has emerged and is spreading rapidly in the Greater Mekong Subregion.

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Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia

December 19, 2017 - 15:26 -- Open Access
Author(s): 
Ankit Dwivedi, Christelle Reynes, Emmanuel Cornillot, et al.
Reference: 
Malaria Journal 2017 16:493, 19 December 2017

Functional analysis of artemisinin resistance subpopulations illustrates the strong interplay between ubiquitination and cell division or differentiation in artemisinin resistant parasites.

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Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

May 16, 2017 - 14:58 -- Open Access
Author(s): 
Angana Mukherjee, Selina Bopp, Sarah K. Volkman, et al.
Reference: 
Malaria Journal 2017 16:195, 12 May 2017

This study of 68 culture-adapted Plasmodium falciparum clinical isolates from Cambodia with known clearance values, associated the D584V PfKelch13 mutation with increased ring-stage survival and identified parasites that lack pfkelch13 mutations yet exhibit increased ring-stage survival.

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Therapeutic efficacy and artemisinin resistance in northern Myanmar: evidence from in vivo and molecular marker studies

April 11, 2017 - 15:50 -- Open Access
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Author(s): 
Moe Kyaw Myint, Charlotte Rasmussen, Aung Thi, Dorina Bustos, Pascal Ringwald and Khin Lin
Reference: 
Malaria Journal 2017 16:143, 7 April 2017

The efficacy of AL, AS + MQ and DP remains high in northern Myanmar despite widespread evidence of k13 mutations associated with delayed parasite clearance.

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Efficacy of artemether–lumefantrine, artesunate–amodiaquine, and dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in Angola, 2015

February 9, 2017 - 14:47 -- Open Access
Author(s): 
Mateusz M. Plucinski, Pedro Rafael Dimbu, Filomeno Fortes, et al.
Reference: 
Malaria Journal 2017 16:62, 2 February 2017

No evidence was found to corroborate the specific allegation of artemisinin resistance in Lunda Sul.

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Emerging polymorphisms in falciparum Kelch 13 gene in Northeastern region of India

December 7, 2016 - 17:30 -- Open Access
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Author(s): 
Neelima Mishra, Ram Suresh Bharti, Neena Valecha, et al.
Reference: 
Malaria Journal 2016 15:583, 3 December 2016

This is the first study to document the presence of F446I NS mutation in the k13 propeller region from Changlang district, Arunachal Pradesh, a site adjoining the Indo-Myanmar border region, where this mutation is highly prevalent.

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