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sporozoite

CD8+ T Effector Memory Cells Protect against Liver-Stage Malaria

July 20, 2011 - 08:55 -- Kabogo Ndegwa
Author(s): 
Arturo Reyes-Sandoval, David H. Wyllie, Karolis Bauza, Anita Milicic, Emily K. Forbes, Christine S. Rollier, and Adrian V. S. Hill
Reference: 
The Journal of Immunology August 1, 2011 vol. 187 no. 3 1347-1357

Identification of correlates of protection for infectious diseases including malaria is a major challenge and has become one of the main obstacles in developing effective vaccines.

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Plasmodium–Host Interactions Directly Influence the Threshold of Memory CD8 T Cells Required for Protective Immunity

May 5, 2011 - 06:34 -- Kabogo Ndegwa
Author(s): 
Nathan W. Schmidt, Noah S. Butler and John T. Harty
Reference: 
The Journal of Immunology May 15, 2011 vol. 186 no. 10 5873-5884

Plasmodium infections are responsible for millions of cases of malaria and ∼1 million deaths annually.

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Calcium signal regulates temperature-dependent transformation of sporozoites in malaria parasite development

April 14, 2011 - 12:39 -- Kabogo Ndegwa
Author(s): 
Yuko Doi, Naoaki Shinzawa, Shinya Fukumoto, Hideyuki Okano, Hirotaka Kanuka
Reference: 
Experimental Parasitology, Volume 128, Issue 2, June 2011, Pages 176-180

The infection by the malaria parasite of its mammalian host is initiated by the asexual reproduction of the parasite within the host hepatocyte.

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Consistent safety and infectivity in sporozoite challenge model of Plasmodium vivax in malaria-naive human volunteers.

February 17, 2011 - 14:05 -- Patrick Sampao
Author(s): 
Herrera S, Solarte Y, Jordán-Villegas A, Echavarría JF, Rocha L, Palacios R, Ramírez O, Vélez JD, Epstein JE, Richie TL, Arévalo-Herrera M.
Reference: 
Am J Trop Med Hyg. 2011 Feb;84(2 Suppl):4-11.

Clinical manifestations of malaria and parasitemia were monitored beginning 7 days post-challenge. All Duffy (+) volunteers developed patent malaria infection within 16 days after challenge.

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Open Access | Oral Presentation: Complete abrogation of sporozoite-induced sterile immunity by blood stage parasites of homologous and heterologous malaria species

November 8, 2010 - 14:48 -- Patrick Sampao
Author(s): 
Megumi Inoue, Jianxia Tang, Osamu Kaneko, Katsuyuki Yui, Richard Culleton
Reference: 
Malaria Journal 2010, 9(Suppl 2):O19 (20 October 2010)

There are ongoing efforts to develop a vaccine based on this system. Attenuation of sporozoites may be achieved via irradiation, genetic modification, or through the use of drugs targeting the blood stage parasite.

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Open Access | Invited Speaker Presentation: Development of an attenuated sporozoite vaccine to prevent and eliminate Plasmodium falciparum malaria

November 3, 2010 - 12:22 -- Patrick Sampao
Author(s): 
Peter F Billingsley
Reference: 
Malaria Journal 2010, 9(Suppl 2):I1 (20 October 2010)

An ideal vaccine for malaria would target all stages of the parasite life cycle, and thereby prevent infection, severe disease and transmission.

ADF2 is required for transformation of the ookinete and sporozoite in malaria parasite development

July 12, 2010 - 13:16 -- Kabogo Ndegwa
Author(s): 
Yuko Doi, Naoaki Shinzawa, Shinya Fukumoto, Hideyuki Okano, Hirotaka Kanuka
Reference: 
Biochemical and Biophysical Research Communications, Volume 397, Issue 4, 9 July 2010, Pages 668-672

Malaria parasites undergo two rounding-up transformations in their life cycle: the ookinete-to-oocyst transformation in the mosquito midgut, and the sporozoite-to-EEF (exo-erythrocytic form) differentiation in the host hepatocyte.

Case report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

October 29, 2009 - 14:33 -- Ingeborg van Schayk
Author(s): 
Sócrates Herrera, Olga Fernández, María R. Manzano, Bermans Murrain, Juana Vergara, Pedro Blanco, Ricardo Palacios, Juan D. Vélez, Judith E. Epstein, Mario Chen-Mok, Zarifah H. Reed, AND Myriam Arévalo-Herrera
Reference: 
Am J Trop Med Hyg 2009;81 740-746

Successful establishment of a Plasmodium vivax sporozoite challenge model in humans is described. In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2–10 An. albimanus mosquitoes carrying P. vivax sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.

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