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vivax

Open Access | Malaria: what can apes teach humans?

August 24, 2010 - 11:38 -- Kabogo Ndegwa
Author(s): 
J Cox-Singh
Reference: 
Future Microbiology August 2010, Vol. 5, No. 8, Pages 1157-1160

Human malaria is caused by four human-host restricted or adapted species of the genus Plasmodium, listed here in their order of risk for causing severe disease Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale and Plasmodium malariae – or so we thought.

Open Access | Detection of mixed Plasmodium falciparum & P. vivax infections by nested-PCR in Pakistan, Iran & Afghanistan

August 12, 2010 - 14:25 -- Kabogo Ndegwa
Author(s): 
Sedigheh Zakeri, Qutbuddin Kakar, Faezeh Ghasemi, Ahmad Raeisi, Waqar Butt, Najibullah Safi, Mandana Afsharpad, Muhammad Suleiman Memon, Saber Gholizadeh, Masoud Salehi, Hoda Atta, Ghasem Zamani, Navid Dinparast Djadid
Reference: 
Indian J Med Res 132, July 2010, pp 31-35

The present data suggest the need for improving microscopy diagnosis method and the clinician should also have careful clinical observation, along with the reports on Giemsa-stained thick blood films, particularly in summer time when P. vivax is predominant.

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Open Access | Malaria rapid diagnostic tests: Plasmodium falciparum infections with high parasite densities may generate false positive Plasmodium vivax pLDH lines

July 12, 2010 - 14:50 -- Kabogo Ndegwa
Author(s): 
Maltha J, Gillet P, Cnops L, van den Ende J, van Esbroeck M, Jacobs J
Reference: 
Malaria Journal 2010, 9:198 (10 July 2010)

False positive Pv-pLDH lines in P. falciparum samples with high parasite density occurred in 6/9 P. vivax-specific RDTs. This is of concern as P. falciparum and P. vivax are co-circulating in many regions. The diagnosis of life-threatening P. falciparum malaria may be missed (two-band Pv-pLDH RDT), or the patient may be treated incorrectly with primaquine (three- or four-band RDTs).

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Inflamation: Heme Impairs Prostaglandin E2 and TGF-β Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria

July 6, 2010 - 06:38 -- Kabogo Ndegwa
Author(s): 
Bruno B. Andrade, Théo Araújo-Santos, Nívea F. Luz, Ricardo Khouri, Marcelo T. Bozza, Luís M. A. Camargo, Aldina Barral, Valéria M. Borges, and Manoel Barral-Netto
Reference: 
The Journal of Immunology, 2010, 185, 1196 -1204

In many hemolytic disorders, such as malaria, the release of free heme has been involved in the triggering of oxidative stress and tissue damage. Patients presenting with severe forms of malaria commonly have impaired regulatory responses.

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Open Access | Heritability of the Human Infectious Reservoir of Malaria Parasites

July 2, 2010 - 11:11 -- Kabogo Ndegwa
Author(s): 
Yaye Ramatoulaye Lawaly, Anavaj Sakuntabhai, Rick Paul, et al
Reference: 
PLoS ONE 5(6): e11358

The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics.

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Open Access | Disorders of Iron Metabolism: Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria

July 1, 2010 - 10:02 -- Kabogo Ndegwa
Author(s): 
Quirijn de Mast, Din Syafruddin, Stephan Keijmel, Teun Olde Riekerink, Oktavian Deky, Puji B. Asih, Dorine W. Swinkels, Andre J. van der Ven
Reference: 
Haematologica, July 2010; 95: 1068 - 1074.

Asymptomatic malarial parasitemia is associated with increased hepcidin concentrations and anemia, in the absence of a manifest acute phase response.

Open Access | Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome

June 29, 2010 - 09:54 -- Kabogo Ndegwa
Author(s): 
Iwagami M, Hwang S, Fukumoto M, Hayakawa T, Tanabe K, Kim S, Kho W, Kano S
Reference: 
Malaria Journal 2010, 9:184 (25 June 2010)

Although the direct introduction of the two P. vivax populations in South Korea were thought to have been from North Korea, the results of this analysis suggest the genealogical origin to be the two different populations in southern China.

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Open Access | Evaluation of a rapid diagnostic test (CareStartTM Malaria HRP-2/pLDH (Pf/pan) Combo Test) for the diagnosis of malaria in a reference setting

June 22, 2010 - 10:06 -- Kabogo Ndegwa
Author(s): 
Maltha J, Gillet P, Bottieau E, Cnops L, van Esbroeck M, Jacobs J
Reference: 
Malaria Journal 2010, 9:171 (18 June 2010)

The CareStartTM Malaria HRP-2/pLDH (Pf/pan) Combo Test performed well for the detection of P. falciparum and P. vivax, but sensitivities for P. ovale and P. malariae were poor.

Technology: 

Heme Impairs Prostaglandin E2 and TGF-β Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria

June 22, 2010 - 09:47 -- Kabogo Ndegwa
Author(s): 
Bruno B. Andrade, Théo Araújo-Santos, Nívea F. Luz, Ricardo Khouri, Marcelo T. Bozza, Luís M. A. Camargo, Aldina Barral, Valéria M. Borges, and Manoel Barral-Netto
Reference: 
J Immunol published 18 June 2010, 10.4049/jimmunol.0904179

In many hemolytic disorders, such as malaria, the release of free heme has been involved in the triggering of oxidative stress and tissue damage. Patients presenting with severe forms of malaria commonly have impaired regulatory responses.

Open Access | Cloning, expression and transmission-blocking activity of anti-PvWARP, malaria vaccine candidate, in Anopheles stephensi mysorensis

June 14, 2010 - 14:13 -- Kabogo Ndegwa
Author(s): 
Gholizadeh S, Basseri H, Zakeri S, Ladoni H, Djadid N
Reference: 
Malaria Journal 2010, 9:158 (11 June 2010)

This is the first report on P. vivax WARP expression in E. coli providing an essential base for development of the malaria TBV against P. vivax. This may greatly assist in malaria elimination, especially in the oriental corner of WHO Eastern Mediterranean Regional Office (WHO/EMRO), including Afghanistan, Iran and Pakistan.

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