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vivax

Proteomic Investigation of Falciparum and Vivax Malaria for Identification of Surrogate Protein Markers

August 22, 2012 - 06:47 -- Kabogo Ndegwa
Author(s): 
Sandipan Ray, Durairaj Renu, Sanjeeva Srivastava, et al.
Reference: 
PLoS ONE 7(8): e41751

MalariaWorldThis study was conducted to analyze alterations in the human serum proteome as a consequence of infection by malaria parasites Plasmodium falciparum and P. vivax to obtain mechanistic insights about disease pathogenesis, host immune response, and identification of potential protein markers.

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Intermittent preventive treatment for malaria in children living in areas with seasonal transmission.

February 21, 2012 - 14:18 -- Patrick Sampao
Author(s): 
Meremikwu MM, Donegan S, Sinclair D, Esu E, Oringanje C.
Reference: 
Cochrane Database Syst Rev. 2012 Feb 15;2

MalariaWorldSeven trials (12,589 participants), including one cluster-randomized trial, met the inclusion criteria. All were conducted in West Africa, and six of seven trials were restricted to children aged less than 5 years.

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Open Access | Using CF11 cellulose columns to inexpensively and effectively remove human DNA from Plasmodium falciparum-infected whole blood samples

February 15, 2012 - 06:43 -- Kabogo Ndegwa
Author(s): 
Venkatesan M, Amaratunga C, Campino S, Auburn S, Koch O, Lim P, Uk S, Socheat D, Kwiatkowski DP, Fairhurst RM, Plowe CV
Reference: 
Malaria Journal 2012, 11:41 (10 February 2012)

MalariaWorldCF11 filtration is a cost-effective, scalable, one-step approach to remove human DNA from P. falciparum-infected whole blood samples.

Open Access | Malaria: Origin of the Term ‘‘Hypnozoite’’

November 24, 2011 - 11:13 -- Ingeborg van Schayk
Author(s): 
Miles B. Markus
Reference: 
Journal of the History of Biology (2011) 44:781–786

Hypnozoites are dormant forms in the life cycles of certain parasitic protozoa that belong to the Phylum Apicomplexa (Sporozoa) and are best known for their probable association with latency and relapse in human malarial infections caused by Plasmodium ovale and P. vivax. 

Open Access | Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women

November 1, 2011 - 07:37 -- Kabogo Ndegwa
Author(s): 
Kattenberg JH, Ochodo EA, Boer KR, Schallig HD, Mens PF, Leeflang MM
Reference: 
Malaria Journal 2011, 10:321 (28 October 2011)

MalariaWorldThe findings suggest that RDTs and PCR may have good performance characteristics to serve as alternatives for the diagnosis of malaria in pregnancy, besides any other limitations and practical considerations concerning the use of these tests.

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Open Access | Detection of high levels of mutations involved in anti-malarial drug resistance in Plasmodium falciparum and Plasmodium vivax at a rural hospital in southern Ethiopia

August 4, 2011 - 10:23 -- Kabogo Ndegwa
Author(s): 
Mula P, Fernandez-Martinez A, de Lucio A, Ramos JM, Reyes F, Gonzalez V, Benito A, Berzosa P
Reference: 
Malaria Journal 2011, 10:214 (2 August 2011)

Current molecular data show an extraordinarily high frequency of drug-resistance mutations in both P. falciparum and P. vivax in southern Ethiopia

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Open Access | Towards an In Vitro Model of Plasmodium Hypnozoites Suitable for Drug Discovery

May 13, 2011 - 12:30 -- Kabogo Ndegwa
Author(s): 
Laurent Dembele, Audrey Gego, Dominique Mazier, et al.
Reference: 
PLoS ONE 6(3): e18162

Resistance of the non-dividing P. cynomolgi forms to atovaquone and pyrimethamine, which do not prevent relapses, strongly suggests that these slow growing forms are hypnozoites.

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Open Access | Comparison of diagnostic methods for the detection and quantification of the four sympatric Plasmodium species in field samples from Papua New Guinea

December 16, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Rosanas-Urgell A, Mueller D, Betuela I, Barnadas C, Iga J, Zimmerman PA, del Portillo HA, Siba P, Mueller I, Felger I
Reference: 
Malaria Journal 2010, 9:361 (14 December 2010)

The qPCR assay developed proved optimal for detection of all four Plasmodium species.

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Open Access | A TaqMan real-time PCR assay for the detection and quantitation of Plasmodium knowlesi

December 2, 2010 - 06:53 -- Kabogo Ndegwa
Author(s): 
Divis PC, Shokoples SE, Singh B, Yanow SK
Reference: 
Malaria Journal 2010, 9:344 (30 November 2010)

This test demonstrated excellent sensitivity and specificity, and adds P. knowlesi to the repertoire of Plasmodium targets for the clinical diagnosis of malaria by real-time PCR assays.

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