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Open Access | Anopheles Gambiae PRS1 Modulates Plasmodium Development at Both Midgut and Salivary Gland Steps

July 16, 2010 - 14:12 -- Kabogo Ndegwa
Thomas Chertemps, Christian Mitri, Sylvie Perrot, Jean Sautereau, Jean-Claude Jacques, Isabelle Thiery, Catherine Bourgouin, Isabelle Rosinski-Chupin
PLoS ONE 5(7): e11538

While providing insights into potential functions of DM9 proteins, our results reveal that PRS1 likely contributes to fundamental interactions between Plasmodium and mosquito epithelia, which do not depend on the specific Anopheles/P. falciparum coevolutionary history.

Report: A Peroxidase/Dual Oxidase System Modulates Midgut Epithelial Immunity in Anopheles gambiae

March 17, 2010 - 08:50 -- Ingeborg van Schayk
Sanjeev Kumar, Alvaro Molina-Cruz, Lalita Gupta, Janneth Rodrigues, Carolina Barillas-Mury
Science DOI: 10.1126/science.1184008

We show that a peroxidase, secreted by the Anopheles gambiae midgut, and dual oxidase form a dityrosine network that decreases gut permeability to immune elicitors.

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