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blood stage

NOT Open Access | Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites

November 16, 2012 - 16:50 -- NOT Open Access
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Author(s): 
Souvik Bhattacharjee, Robert V. Stahelin, Kasturi Haldar
Reference: 
Trends in Parasitology, Volume 28, Issue 12, December 2012, Pages 555-562
MalariaWorld

We discuss a model of PI(3)P-dependent targeting and PI(3)P biology of a major human pathogen.

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Open Access | Glutathione Reductase-null Malaria Parasites Have Normal Blood Stage Growth but Arrest during Development in the Mosquito

August 25, 2010 - 08:48 -- Kabogo Ndegwa
Author(s): 
Rebecca Pastrana-Mena, Rhoel R. Dinglasan, Adelfa E. Serrano, et al
Reference: 
The Journal of Biological Chemistry, August 27, 2010, 285 27045-27056

Malaria parasites contain a complete glutathione (GSH) redox system, and several enzymes of this system are considered potential targets for antimalarial drugs.

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Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth

March 31, 2010 - 11:30 -- Patrick Sampao
Author(s): 
Joseph T. Bruder, Maureen E. Stefaniak, Noelle B. Patterson, Ping Chen, Svetlana Konovalova, Keith Limbach, Joseph J. Campo, Damodar Ettyreddy, Sheng Li, Filip Dubovsky, Thomas L. Richie, C. Richter King, Carole A. Long, Denise L. Doolan
Reference: 
Vaccine, Volume 28, Issue 18, 19 April 2010, Pages 3201-3210

These data highlight the importance of rational vaccine design and support the advancement of adenovector delivery technology for a malaria vaccine.

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Medical Condition: 
Medical Treatment: 

Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice

March 15, 2010 - 13:55 -- Ingeborg van Schayk
Author(s): 
Ahmed S. I. Aly, Megan J. Downie, Choukri Ben Mamoun and Stefan H. I. Kappe
Reference: 
Cellular Microbiology Early View

The study demonstrates that genetic manipulation provides a platform for the designed, complete attenuation of malaria parasite blood stages and suggests testing the safety and efficacy of P. falciparum NT1 knockout strains in humans.

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