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Open Access | Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis

May 25, 2011 - 08:57 -- Kabogo Ndegwa
Tommasi C, Bellagamba R, Tempestilli M, D'Avolio A, Gallo AL, Ivanovic J, Nicastri E, Pucillo LP, Narciso P
Malaria Journal 2011, 10:141 (21 May 2011)

The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported.

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Open Access | Sequence similarity between the erythrocyte binding domain 1 of the Plasmodium vivax Duffy Binding Protein and the V3 loop of HIV-1 strain MN reveals binding residues for the Duffy Antigen Receptor for Chemokines

February 4, 2011 - 08:03 -- Patrick Sampao
Bolton MJ, Garry RF
Virology Journal 2011, 8:45 (31 January 2011)

Variable loop 3 (V3) of HIV-1 SU and subdomain 1 of the Plasmodium vivax DBP share a sequence similarity. The site of amino acid sequence similarity was necessary, but not sufficient, for DARC binding and contained a consensus heparin binding site essential for DARC binding. Both HIV-1 and P. vivax can be blocked from binding to their chemokine receptors by the chemokine, RANTES and its analog AOP-RANTES.

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Viewpoint: African Burkitt's lymphoma: could collaboration with HIV-1 and malaria programmes reduce the high mortality rate?

May 10, 2010 - 12:54 -- Patrick Sampao
Sam M Mbulaiteye, Ambrose O Talisuna, Martin D Ogwang, F Ellis McKenzie, John L Ziegler, Donald M Parkin
The Lancet, Volume 375, Issue 9726, 8 May 2010-14 May 2010, Pages 1661-1663

No abstract available

Natural Disaster: 

Malaria hemozoin modulates susceptibility of immature monocyte-derived dendritic cells to HIV-1 infection by inducing a mature-like phenotype

March 15, 2010 - 11:18 -- Ingeborg van Schayk
Juliette Diou, Mélanie R. Tardif, Corinne Barat and Michel J. Tremblay
Cellular Microbiology, Early View

There is still limited information about the putative impact of the malaria pigment hemozoin (HZ) on the dissemination of HIV-1. As so, we propose a premise where HZ present in human dendritic cells (DCs) could modulate HIV-1 transfer to CD4+ T cells. 

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