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RNA aptamers

In vitro selection of RNA aptamers against a conserved region of the Plasmodium falciparum erythrocyte membrane protein 1

October 29, 2009 - 14:18 -- Ingeborg van Schayk
Author(s): 
Anders Barfod, Tina Persson & Johan Lindh
Reference: 
Parasitology Research, Volume 105, Number 6 / November, 2009 : 1557-1566, DOI 10.1007/s00436-009-1583-x

In this study we use Systematic Evolution of Ligands by EXponential enrichment (SELEX) methodology to isolate high-affinity ligands (aptamers). To validate the results from the SELEX in vitro selection, different aptamers have been selected against PfEMP1 in a live cell assay of P. falciparum strain FCR3S1.2, a highly rosetting strain.

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