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Plasmodium falciparum malaria

Comparison of malaria incidence rates and socioeconomic-environmental factors between the states of Acre and Rondônia: a spatio-temporal modelling study

September 13, 2019 - 06:50 -- Open Access
Author(s): 
Meyrecler Aglair de Oliveira Padilha, Janille de Oliveira Melo, Guilherme Romano, Marcos Vinicius Malveira de Lima, Wladimir J. Alonso, Maria Anice Mureb Sallum and Gabriel Zorello Laporta
Reference: 
Malaria Journal 2019 18:306, 4 September 2019

Plasmodium falciparum malaria is a threat to public health, but Plasmodium vivax malaria is most prevalent in Latin America, where the incidence rate has been increasing since 2016, particularly in Venezuela and Brazil. The Brazilian Amazon reported 193,000 cases in 2017, which were mostly confirmed as P. vivax (~ 90%). Herein, the relationships among malaria incidence rates and the proportion of accumulated deforestation were contrasted using data from the states of Acre and Rondônia in the south-western Brazilian Amazon. The main purpose is to test the hypothesis that the observed difference in incidence rates is associated with the proportion of accumulated deforestation.

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Predictors of Plasmodium falciparum Malaria Incidence in Chano Mille, South Ethiopia: A Longitudinal Study

September 7, 2012 - 04:06 -- Patrick Sampao
Author(s): 
Eskindir Loha and Bernt Lindtjørn
Reference: 
Am J Trop Med Hyg 2012 87:450-459

MalariaWorldWe assessed potential effects of local meteorological and environmental conditions, indoor residual spraying with insecticides, insecticide-treated nets (ITNs) use at individual and community levels, and individual factors on Plasmodium falciparum malaria incidence in a village in south Ethiopia.

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Arterolane, a New Synthetic Trioxolane for Treatment of Uncomplicated Plasmodium falciparum Malaria: A Phase II, Multicenter, Randomized, Dose-Finding Clinical Trial

August 10, 2010 - 09:38 -- Kabogo Ndegwa
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Author(s): 
N Valecha, S Looareesuwan, A Martensson, SM Abdulla, S Krudsood, N Tangpukdee, S Mohanty, SK Mishra, PK Tyagi, SK Sharma, J Moehrle, A Gautam, A Roy, JK Paliwal, M Kothari, N Saha, AP Dash, A örkman
Reference: 
Clinical Infectious Diseases 2010;51:000–000

Arterolane at daily doses of 100 and 200 mg is a rapidly acting, effective, and safe synthetic antimalarial drug, which may potentially represent an alternative to artemisinin derivatives in antimalarial combination therapy.

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Open Access | The Relationship between Anti-merozoite Antibodies and Incidence of Plasmodium falciparum Malaria: A Systematic Review and Meta-analysis

January 19, 2010 - 19:56 -- Ingeborg van Schayk
Author(s): 
Freya J. I. Fowkes, Jack S. Richards, Julie A. Simpson, James G. Beeson
Reference: 
PLoS Med 7(1): e1000218

A systematic review and meta-analysis examining the association between anti-merozoite antibody responses and incidence of Plasmodium falciparum malaria by Freya Fowkes and colleagues aids identification of antigens that confer protection from malaria.

Open Access | Antigen-specific influence of GM/KM allotypes on IgG isotypes and association of GM allotypes with susceptibility to Plasmodium falciparum malaria

January 5, 2010 - 20:55 -- Ingeborg van Schayk
Author(s): 
Hayder A Giha, Amre Nasr, Nnaemeka C Iriemenam, David Arnot, Marita Troye-Blomberg, Thor G Theander, Klavs Berzins, Gehad ElGhazali, Janardan P Pandey
Reference: 
Malaria Journal 2009, 8:306 (22 December 2009)

The GM allotypes have significant influence on susceptibility to uncomplicated P. falciparum malaria and antigen-dependent influence on total IgG and IgG subclasses.

Review: Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria

December 29, 2009 - 13:52 -- Patrick Sampao
Author(s): 
Prof Stephen J Rogerson FRACP, Rushika S Wijesinghe MD, and Steven R Meshnick MD
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 1, January 2010, Pages 51-59

Improved methods for assessing antimalarial immunity will strengthen malaria control efforts.

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Synthesis and structure–activity relationships of cassiarin A as potential antimalarials with vasorelaxant activity.

November 18, 2009 - 12:54 -- Kabogo Ndegwa
Author(s): 
Hiroshi Morita, Yuichiro Tomizawa, Jun Deguchi, Tokio Ishikawa, Hiroko Arai, Kazumasa Zaima, Takahiro Hosoya, Yusuke Hirasawa, Takayuki Matsumoto, Katsuo Kamata, Wiwied Ekasari, Aty Widyawaruyanti, Tutik Sri Wahyuni, Noor Cholies Zaini, Toshio Honda.
Reference: 
Bioorganic & Medicinal Chemistry, Volume 17, Issue 24, 15 December 2009, Pages 8234-8240, doi:10.1016/j.bmc.2009.10.013

Cassiarin A 1, a tricyclic alkaloid, isolated from the leaves of Cassia siamea (Leguminosae), shows powerful antimalarial activity against Plasmodium falciparum in vitro as well as P. berghei in vivo, which may be valuable leads for novel antimalarials.

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The development and evaluation of a single step multiplex PCR for simultaneous detection of Anopheles annularis group mosquitoes, human host preference and Plasmodium falciparum sporozoite presence

October 25, 2009 - 17:45 -- Bart G.J. Knols
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Author(s): 
Sunita Swain, Amitav Mohanty, Namita Mahapatra, S.K. Parida, N.S. Marai, H.K. Tripathy, Santanu K. Kar, Rupenangshu K. Hazra
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1146-1152, doi:10.1016/j.trstmh.2009.03.022

The Anopheles annularis group mosquitoes, subgenus Cellia Theobald (Diptera: Culicidae), includes five recognized species: An. annularis Van der Wulp, An. nivipes Theobald, An. pallidus Theobald, An. philippinensis Ludlow and An. schueffneri Stanton. From these five, the three most common species found in Orissa were considered for this study because of their remarkable vectorial and behavioral variation and the important role they play in malaria transmission. To identify and understand their role in malaria transmission we developed a single multiplex PCR-based assay.  This one-step PCR-based method constitutes a very powerful tool in large surveys of anopheline populations.

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Heritability of Antibody Isotype and Subclass Responses to Plasmodium falciparum Antigens

October 25, 2009 - 16:06 -- Bart G.J. Knols
Author(s): 
Tetteh KKA, Whittle HC, et al.
Reference: 
PLoS ONE 4(10): e7381. doi:10.1371/journal.pone.0007381

Genome-wide approaches are now warranted to map the major genetic determinants of variable antibody isotype and subclass responses to malaria, alongside evaluation of their impact on infection and disease. Although plasma levels of IgG4 to malaria antigens are generally low, the exceptionally high heritability of levels of this subclass in children deserves particular investigation.

 

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Absence of Erythrocyte Sequestration and Lack of Multicopy Gene Family Expression in Plasmodium falciparum from a Splenectomized Malaria Patient

October 25, 2009 - 16:01 -- Bart G.J. Knols
Author(s): 
Predehl S, von Kalckreuth V, et al.
Reference: 
PLoS ONE 4(10): e7459. doi:10.1371/journal.pone.0007459

This case strongly supports the hypothesis that parasite surface proteins such as PfEMP1, A-type RIFIN or STEVOR are involved in interactions of infected erythrocytes with endothelial receptors mediating sequestration of mature asexual and immature sexual stages of P. falciparum. In contrast, multicopy gene families coding for B-type RIFIN and PfMC-2TM proteins may not be involved in sequestration, as these genes were transcribed in infected but not sequestered erythrocytes.

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