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malarial dihydrofolate reductases

Open Access | Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

March 7, 2010 - 12:56 -- Ingeborg van Schayk
Author(s): 
Kiattawee Choowongkomon, Sasikrit Theppabutr, Napat Songtawee, Nicholas PJ Day, Nicholas J White, Charles J Woodrow, Mallika Imwong
Reference: 
Malaria Journal 2010, 9:65 (2 March 2010)

Here the interactions between DHFR inhibitors and modelled structures of the DHFR enzymes of Plasmodium malariae (PmDHFR) and Plasmodium ovale (PoDHFR) are described, along with an investigation of the effect of recently reported mutations within PmDHFR.

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