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pfmdr1

pfmdr1 Amplification and Fixation of pfcrt Chloroquine Resistance Alleles in Plasmodium falciparum in Venezuela

March 25, 2010 - 20:25 -- Patrick Sampao
Author(s): 
Sean Griffing,Luke Syphard,Sankar Sridaran, Andrea M. McCollum,Tonya Mixson-Hayden, Sumiti Vinayak,Leopoldo Villegas,John W. Barnwell, Ananias A. Escalante, and Venkatachalam Udhayakumar
Reference: 
Antimicrobial Agents and Chemotherapy, April 2010, p. 1572-1579, Vol. 54, No. 4

In order to assess how historical drug policies impacted Plasmodium falciparum in Venezuela, we examined molecular changes in genes associated with drug resistance.

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Short communication: Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso

March 5, 2010 - 11:00 -- Kabogo Ndegwa
Author(s): 
Ina Danquah, Boubacar Coulibaly, Peter Meissner, Inga Petruschke, Olaf Müller, Frank P. Mockenhaupt
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 63-66

The weak association of pfmdr1/pfcrt alleles with amodiaquine treatment outcome suggests further factors to be involved in the unsatisfactory low efficacy of the drug and limits the usefulness of these markers in this area.

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