In order to assess how historical drug policies impacted Plasmodium falciparum in Venezuela, we examined molecular changes in genes associated with drug resistance.
Antimicrobial Agents and Chemotherapy, April 2010, p. 1572-1579, Vol. 54, No. 4
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 63-66
The weak association of pfmdr1/pfcrt alleles with amodiaquine treatment outcome suggests further factors to be involved in the unsatisfactory low efficacy of the drug and limits the usefulness of these markers in this area.