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parasite

Not Open Access | Metamorphoses of malaria: the role of autophagy in parasite differentiation.

June 18, 2012 - 15:23 -- Patrick Sampao
Author(s): 
Coppens I
Reference: 
Essays Biochem. 2011;51:127-36

MalariaWorldAn exciting prospect derived from these observations is that the parasite proteins involved in the autophagic process may represent new targets for drug development.

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Restricted | Whole parasite vaccination approaches for prevention of malaria infection

May 4, 2012 - 14:08 -- Patrick Sampao
Author(s): 
Noah S. Butler, Ashley M. Vaughan, John T. Harty, Stefan H.I. Kappe
Reference: 
Trends in Immunology, Volume 33, Issue 5, May 2012, Pages 247-254

MalariaWorldThis model gave the rationale for development of recombinant and vectored subunit vaccination strategies that have, however, not yet matched whole sporozoite protective efficacy.

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Unraveling the Ubiquitome of the Human Malaria Parasite

November 16, 2011 - 09:26 -- Patrick Sampao
Author(s): 
Nadia Ponts, Anita Saraf, Duk-Won D. Chung, Alona Harris, Jacques Prudhomme, Michael P. Washburn, Laurence Florens and Karine G. Le Roch
Reference: 
Journal of Biological Chemistry, 286, 40320-40330.

MalariaWorldHere, we combined immunofluorescent microscopy, biochemical assays, in silico prediction, and mass spectrometry analysis using the multidimensional protein identification technology, or MudPIT, to describe the P. falciparum ubiquitome.

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Review: Gametocytogenesis in malaria parasite: commitment, development and regulation

November 16, 2011 - 08:45 -- Patrick Sampao
Author(s): 
Zhenyu Liu, Jun Miao & Liwang Cui
Reference: 
Future Microbiology, November 2011, Vol. 6, No. 11, Pages 1351-1369

MalariaWorldThis article provides an update of our understanding of the molecular and cellular events associated with the decision for commitment to sexual development and regulation of gene expression during gametocytogenesis.

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Metamorphoses of malaria: the role of autophagy in parasite differentiation.

October 27, 2011 - 13:27 -- Patrick Sampao
Author(s): 
Coppens I.
Reference: 
Essays Biochem. 2011 Oct 24;51:127-36.

MalariaWorldAn exciting prospect derived from these observations is that the parasite proteins involved in the autophagic process may represent new targets for drug development.

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Letter: Induction of Malaria Parasite Migration by Synthetically Tunable Microenvironments

September 28, 2011 - 07:34 -- Patrick Sampao
Author(s): 
Nadine Perschmann, Janina Kristin Hellmann, Friedrich Frischknecht, and Joachim P. Spatz
Reference: 
Nano Lett., September 12, 2011

Our results and approaches provide the basis for a precise dissection of the mechanisms underlying Plasmodium sporozoites migration.

Type I interferons suppress CD4+ T-cell-dependent parasite control during blood-stage Plasmodium infection

August 30, 2011 - 12:06 -- Patrick Sampao
Author(s): 
Ashraful Haque, Shannon E. Best, Christian R. Engwerda, et al.
Reference: 
European Journal of Immunology, Volume 41, Issue 9, pages 2688–2698, September 2011

Here, we observed IFN-α protein production in the spleen of PbA-infected C57BL/6 mice over the first 2 days of infection.

Quantitative Time-course Profiling of Parasite and Host Cell Proteins in the Human Malaria Parasite Plasmodium falciparum

August 3, 2011 - 12:15 -- Patrick Sampao
Author(s): 
Bernardo Javier Foth, Neng Zhang, Balbir Kaur Chaal, Siu Kwan Sze, Peter Rainer Preiser and Zbynek Bozdech
Reference: 
Molecular & Cellular Proteomics, M110.006411. August 1, 2011

Together, our data provide fundamental insights into transcript-protein relationships in P. falciparum that are important for the correct interpretation of transcriptional data and that may facilitate the improvement and development of malaria diagnostics and drug therapy.

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Short Report: Ivermectin Mass Drug Administration to Humans Disrupts Malaria Parasite Transmission in Senegalese Villages

July 7, 2011 - 13:51 -- Patrick Sampao
Author(s): 
Kevin C. Kobylinski, Massamba Sylla, Phillip L. Chapman, Moussa D. Sarr and Brian D. Foy
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 1 3-5

We report that ivermectin MDA reduced the proportion of Plasmodium falciparum infectious Anopheles gambiae sensu stricto (s.s.) in treated villages in southeastern Senegal.

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Short Technical Report: Polysome profiling of the malaria parasite Plasmodium falciparum

June 27, 2011 - 14:54 -- Patrick Sampao
Author(s): 
Joshua R. Lacsina, Gregory LaMonte, Christopher V. Nicchitta, Jen-Tsan Chi
Reference: 
Molecular and Biochemical Parasitology, Volume 179, Issue 1, September 2011, Pages 42-46

We describe here a novel method for polysome profiling in P. falciparum, a powerful approach which allows both a global view of translation and the measurement of ribosomal loading and density for specific mRNAs.

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