We used local spatial statistics and geographically weighted regression (GWR) to determine the spatial pattern of malaria incidence and persistence in northeastern Venezuela.
Such data may have implications for determining the best route and dose of administration to humans of our attenuated P. falciparum sporozoite vaccine, the scientific basis of which is immunity by bites from irradiated infected mosquitoes, and suggest that the challenge is to develop a method of administration that approximates IV inoculation, not one that mimics mosquito bite.
The authors developed a method to count fluorescent malaria parasite oocysts on mosquito midgut. This method should speed up the process of counting malaria parasites and limit data variation due to the observer. They present data highlighting the use of this method to increasing throughput for evaluating the transmission blocking potential of selected anti-malarial drugs.
No abstract available.
This study highlights that increased ITN coverage led to significant reduction in risk exposure and malaria incidence only when treated nets yielded high killing effects. It is necessary to test efficacy of treated nets on local dominant vector mosquitoes, at least in laboratory, for monitoring and evaluation of ITN programmes.
The clinical presentation of pregnancy-associated malaria depends crucially on the particular epidemiological settings. By re-examining historical data, and the use of a simple mathematical model, it is demonstrated how excess female mortality can be used to evaluate the burden of pregnancy-associated malaria.