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Disentangling the Effect of Local and Global Spatial Variation on a Mosquito-Borne Infection in a Neotropical Heterogeneous Environment

February 10, 2010 - 13:45 -- Ingeborg van Schayk
María-Eugenia Grillet, Roberto Barrera, Juan-Eudes Martínez, Jesús Berti, AND Marie-Josée Fortin
Am J Trop Med Hyg 2010;82 194-201

We used local spatial statistics and geographically weighted regression (GWR) to determine the spatial pattern of malaria incidence and persistence in northeastern Venezuela.

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Open Access | Plasmodium yoelii-Infected A. stephensi Inefficiently Transmit Malaria Compared to Intravenous Route

February 9, 2010 - 13:32 -- Ingeborg van Schayk
Solomon Conteh, Rana Chattopadhyay, Charles Anderson, Stephen L. Hoffman
PLoS ONE 5(1): e8947

Such data may have implications for determining the best route and dose of administration to humans of our attenuated P. falciparum sporozoite vaccine, the scientific basis of which is immunity by bites from irradiated infected mosquitoes, and suggest that the challenge is to develop a method of administration that approximates IV inoculation, not one that mimics mosquito bite.

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Open Access | Methodology: A semi-automated method for counting fluorescent malaria oocysts increases the throughput of transmission blocking studies

January 29, 2010 - 15:14 -- Ingeborg van Schayk
Michael J Delves, Robert E Sinden
Malaria Journal 2010, 9:35 (29 January 2010)

The authors developed a method to count fluorescent malaria parasite oocysts on mosquito midgut. This method should speed up the process of counting malaria parasites and limit data variation due to the observer. They present data highlighting the use of this method to increasing throughput for evaluating the transmission blocking potential of selected anti-malarial drugs.

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Predicting the impact of insecticide-treated bed nets on malaria transmission: the devil is in the detail

November 26, 2009 - 11:41 -- Ingeborg van Schayk
Weidong Gu, Robert J Novak
Malaria Journal 2009, 8:256 (16 November 2009)

This study highlights that increased ITN coverage led to significant reduction in risk exposure and malaria incidence only when treated nets yielded high killing effects. It is necessary to test efficacy of treated nets on local dominant vector mosquitoes, at least in laboratory, for monitoring and evaluation of ITN programmes.

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Assessing the burden of pregnancy-associated malaria under changing transmission settings

October 29, 2009 - 12:47 -- Ingeborg van Schayk
Mario Recker, Menno J Bouma, Paul Bamford, Sunetra Gupta, Andy P Dobson
Malaria Journal 2009, 8:245 (28 October 2009)

The clinical presentation of pregnancy-associated malaria depends crucially on the particular epidemiological settings. By re-examining historical data, and the use of a simple mathematical model, it is demonstrated how excess female mortality can be used to evaluate the burden of pregnancy-associated malaria.

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