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Differences in Erythrocyte Receptor Specificity of Different Parts of the Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a

July 26, 2011 - 12:48 -- Patrick Sampao
Author(s): 
Karthigayan Gunalan, Xiaohong Gao, Kingsley J. L. Liew, and Peter R. Preiser
Reference: 
Infect. Immun., Aug 2011; 79: 3421 - 3430.

Here, using monoclonal antibodies raised against a unique region of PfRH2a, we show that PfRH2a moves from the rhoptry neck to the moving junction during merozoite invasion.

Medical Treatment: 

Open Access | The Major Yolk Protein Vitellogenin Interferes with the Anti-Plasmodium Response in the Malaria Mosquito Anopheles gambiae

July 21, 2010 - 11:59 -- Kabogo Ndegwa
Author(s): 
Martin K. Rono, Miranda M. A. Whitten, Mustapha Oulad-Abdelghani, Elena A. Levashina, Eric Marois
Reference: 
PLoS Biol 8(7): e1000434

When taking a blood meal on a person infected with malaria, female Anopheles gambiae mosquitoes, the major vector of human malaria, acquire nutrients that will activate egg development (oogenesis) in their ovaries.

Open Access | Protein Kinase A Dependent Phosphorylation of Apical Membrane Antigen 1 Plays an Important Role in Erythrocyte Invasion by the Malaria Parasite

June 29, 2010 - 09:43 -- Kabogo Ndegwa
Author(s): 
Kerstin Leykauf, Moritz Treeck, Paul R. Gilson, Thomas Nebl, Thomas Braulke, Alan F. Cowman, Tim W. Gilberger, Brendan S. Crabb
Reference: 
PLoS Pathog 6(6): e1000941

Apicomplexan parasites are obligate intracellular parasites that infect a variety of hosts, causing significant diseases in livestock and humans. The invasive forms of the parasites invade their host cells by gliding motility, an active process driven by parasite adhesion proteins and molecular motors.

Open Access | Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests

May 18, 2010 - 13:11 -- Kabogo Ndegwa
Author(s): 
Baker J, Ho M, Cheng Q,. et al
Reference: 
Malaria Journal 2010, 9:129 (17 May 2010)

The results suggest that despite extreme sequence variation, diversity of PfHRP2 does not appear to be a major cause of RDT sensitivity variation.

Technology: 

Plasmodium falciparum PF10_0164 (ETRAMP10.3) Is an Essential Parasitophorous Vacuole and Exported Protein in Blood Stages

May 4, 2010 - 09:46 -- Patrick Sampao
Author(s): 
Drew C. MacKellar, Matthew T. O'Neill, Ahmed S. I. Aly, John B. Sacci, Jr., Alan F. Cowman, and Stefan H. I. Kappe
Reference: 
Eukaryot. Cell, May 2010; 9: 784 - 794.

We show that PF10_0164 is expressed in sporozoites and blood stages of P. falciparum, where it localizes to the parasitophorous vacuole, and is also exported to the host erythrocyte. PF10_0164 is refractory to disruption in asexual blood stages.

Open Access | Functional Evaluation of Plasmodium Export Signals in Plasmodium berghei Suggests Multiple Modes of Protein Export

April 22, 2010 - 13:09 -- Kabogo Ndegwa
Author(s): 
Puran Singh Sijwali, Philip J. Rosenthal
Reference: 
PLoS ONE 5(4): e10227

Functional validation of common putative export domains of malaria parasites in P. berghei provides an alternative and simpler system to investigate export mechanisms.

Technology: 

Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug

March 25, 2010 - 20:12 -- Patrick Sampao
Author(s): 
Jacob H. Rand, Xiao-Xuan Wu, Anthony S. Quinn, Anthony W. Ashton, Pojen P. Chen, James J. Hathcock, Harry A. M. Andree, and Douglas J. Taatjes
Reference: 
Blood, 18 March 2010, Vol. 115, No. 11, pp. 2292-2299.

In conclusion, HCQ reversed antiphospholipid-mediated disruptions of AnxA5 on PLBs and cultured cells, and in APS patient plasmas. These results support the concept of novel therapeutic approaches that address specific APS disease mechanisms.

Medical Condition: 

Protein-DNA Complex Is the Exclusive Malaria Parasite Component that Activates Dendritic Cells and Triggers Innate Immune Responses

March 21, 2010 - 11:06 -- Ingeborg van Schayk
Author(s): 
Xianzhu Wu, Nagaraj M. Gowda, Sanjeev Kumar, and D. Channe Gowda
Reference: 
J. Immunol. published 15 March 2010, 10.4049/jimmunol.0903824

Together, these results contribute substantially toward the understanding of malaria parasite-recognition mechanisms. More importantly, our finding that proteins and carbohydrate polymers are able to confer stimulatory activity to an otherwise inactive parasite DNA have important implications for the development of a vaccine against malaria.

Medical Treatment: 

Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein of blood stages

March 21, 2010 - 10:51 -- Ingeborg van Schayk
Author(s): 
Drew C. MacKellar, Matthew T. O'Neill, Ahmed S.I. Aly, John B. Sacci, Jr, Alan F. Cowman, and Stefan H.I. Kappe
Reference: 
Eukaryot. Cell. published 12 March 2010, 10.1128/EC.00336-09

We show that PF10_0164 is expressed in sporozoites and blood stages of P. falciparum, where it localizes to the parasitophorous vacuole, and is also exported to the host erythrocyte.

Expression, purification, and structural analysis of Iranian Plasmodium vivax von Willebrand factor A domain-related protein (PvWARP)

March 17, 2010 - 09:02 -- Ingeborg van Schayk
Author(s): 
S. Gholizadeh, N. Dinparast Djadid, H.R. Basseri, S. Zakeri, H. Ladoni
Reference: 
New Biotechnology, Volume 27, Supplement 1, April 2010, Page S73

No abstract available 

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