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Open Access | Malaria: Origin of the Term ‘‘Hypnozoite’’

November 24, 2011 - 11:13 -- Ingeborg van Schayk
Miles B. Markus
Journal of the History of Biology (2011) 44:781–786

Hypnozoites are dormant forms in the life cycles of certain parasitic protozoa that belong to the Phylum Apicomplexa (Sporozoa) and are best known for their probable association with latency and relapse in human malarial infections caused by Plasmodium ovale and P. vivax. 

Review: Targeting the hypnozoite reservoir of Plasmodium vivax: the hidden obstacle to malaria elimination

February 26, 2010 - 10:45 -- Kabogo Ndegwa
Timothy N.C. Wells, Jeremy N. Burrows, J. Kevin Baird
Trends in Parasitology, Volume 26, Issue 3, March 2010, Pages 145-151

The only clinical therapy against relapse of vivax malaria is the 8-aminoquinoline, primaquine. New, safer and more-easily administered drugs are urgently needed, and this is a crucial gap in the broader malaria-elimination agenda.

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