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transmission

Open Access | A quantitative analysis of transmission efficiency versus intensity for malaria

January 18, 2012 - 11:38 -- Patrick Sampao
Author(s): 
David L. Smith, Chris J. Drakeley, Christinah Chiyaka & Simon I. Hay
Reference: 
Nature Communications Volume: 1:108

MalariaWorldIn this study, we show that these studies trace a strongly nonlinear relationship between malaria transmission intensity and efficiency that is parsimoniously described by a model of heterogeneous biting.

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Can we depend on case management to prevent re-establishment of P. falciparum malaria, after local interruption of transmission?

December 7, 2011 - 14:35 -- Patrick Sampao
Author(s): 
Valerie Crowell, Diggory Hardy, Olivier Briët, Nakul Chitnis, Nicolas Maire, Thomas Smith
Reference: 
Epidemics, Volume 4, Issue 1, March 2012, Pages 1-8

MalariaWorldWe assess, through mathematical modeling and simulation, which levels of case detection and treatment (case management) are required to prevent re-establishment of transmission of P. falciparum after local interruption of transmission has been achieved, in settings with varying receptivity and vulnerability.

Open Access | Variations in salinity tolerance of malaria vectors of the Anopheles subpictus complex in Sri Lanka and the implications for malaria transmission

June 27, 2011 - 12:55 -- Patrick Sampao
Author(s): 
Surendran SN, Jude PJ, Ramasamy R
Reference: 
Parasites & Vectors 2011, 4:117 (24 June 2011)

The results suggest that An. subpictus species B/An. sundaicus breed in fresh, brackish and nearly saline water while An. subpictus species C and D do so in fresh and less brackish waters in Sri Lanka as in India.

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Open Access | Plasmodium falciparum Genetic Diversity Maintained and Amplified Over 5 Years of a Low Transmission Endemic in the Peruvian Amazon

June 14, 2011 - 14:12 -- Patrick Sampao
Author(s): 
OraLee H. Branch, Patrick L. Sutton, Carmen Barnes, Juan Carlos Castro, Julie Hussin, Philip Awadalla and Gisely Hijar
Reference: 
Mol Biol Evol (2011) 28 (7): 1973-1986.

We examined parasite population structure and traced the parasite genetic diversity temporally and spatially. We genotyped infections over 5 years (2003–2007) using 14 microsatellite (MS) markers scattered across ten different chromosomes. Despite low transmission, there was considerable genetic diversity, which we compared with other geographic regions.

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Open Access | Modelling the global constraints of temperature on transmission of Plasmodium falciparum and P. vivax

June 1, 2011 - 07:10 -- Patrick Sampao
Author(s): 
Gething PW, Van Boeckel TP, Smith DL, Guerra CA, Patil AP, Snow RW, Hay SI
Reference: 
Parasites & Vectors 2011, 4:92 (26 May 2011)

We defined a dynamic biological model that incorporated the principal mechanisms of temperature dependency in the malaria transmission cycle and used it with fine spatial and temporal resolution temperature data to evaluate time-series of temperature suitability for transmission of Plasmodium falciparum and P. vivax throughout an average year, quantified using an index proportional to the basic reproductive number.

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Open Access | Identification of malaria transmission and epidemic hotspots in the Western Kenya highlands: its application to malaria epidemic prediction.

May 28, 2011 - 10:12 -- Patrick Sampao
Author(s): 
Christine L Wanjala, John Waitumbi, Guofa Zhou and Andrew K Githeko
Reference: 
Parasites & Vectors 2011, 4:81

This study showed that the V-shaped ecosystems have very low malaria prevalence and few individuals with an immune response to two major malaria antigens and they can be considered as epidemic hotspots.

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Continuing Intense Malaria Transmission in Northern Uganda

May 4, 2011 - 14:55 -- Patrick Sampao
Author(s): 
Carla Proietti, Davide D. Pettinato, Bernard N. Kanoi, Edward Ntege, Andrea Crisanti, Eleanor M. Riley, Thomas G. Egwang, Chris Drakeley, AND Teun Bousema
Reference: 
Am J Trop Med Hyg, May 2011; 84: 830 - 837.

We determined malaria parasite carriage and age-dependent antibody responses to Plasmodium falciparum antigens in cross-sectional surveys in Apac, northern Uganda that was affected by political unrest. Under-five parasite prevalence was 55.8% (115/206) by microscopy and 71.9% (41/57) by polymerase chain reaction.

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Opinion: Uses of mosquito-stage transmission-blocking vaccines against Plasmodium falciparum

April 29, 2011 - 10:21 -- Patrick Sampao
Author(s): 
Thomas A. Smith, Nakul Chitnis, Olivier J.T. Briët, Marcel Tanner
Reference: 
Trends in Parasitology, Volume 27, Issue 5, May 2011, Pages 190-196

A quantitative framework is used to explore the potential applications and probable effects of sexual stage or mosquito stage transmission blocking vaccines (TBVs) against malaria.

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Opinion: Malaria and trypanosome transmission: different parasites, same rules?

April 29, 2011 - 08:54 -- Patrick Sampao
Author(s): 
Laura C. Pollitt, Paula MacGregor, Keith Matthews, Sarah E. Reece
Reference: 
Trends in Parasitology, Volume 27, Issue 5, May 2011, Pages 197-203

An evolutionary approach has the power to explain why patterns of investment vary between strains and during infections, giving important insights into parasite biology.

Opinion: Malaria crystalloids: specialized structures for parasite transmission?

March 9, 2011 - 07:54 -- Patrick Sampao
Author(s): 
Johannes T. Dessens, Sadia Saeed, Annie Z. Tremp, Victoria Carter
Reference: 
Trends in Parasitology, Volume 27, Issue 3, March 2011, Pages 106-110

Nearly five decades after they were first described, the crystalloids are back in the spotlight, with recent discoveries pointing to an important role in protein trafficking and sporozoite transmission that could be exploited as new targets for control of malaria transmission.

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