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von Willebrand factor

Expression, purification, and structural analysis of Iranian Plasmodium vivax von Willebrand factor A domain-related protein (PvWARP)

March 17, 2010 - 09:02 -- Ingeborg van Schayk
Author(s): 
S. Gholizadeh, N. Dinparast Djadid, H.R. Basseri, S. Zakeri, H. Ladoni
Reference: 
New Biotechnology, Volume 27, Supplement 1, April 2010, Page S73

No abstract available 

Country: 

Brief report: Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

February 25, 2010 - 13:39 -- Kabogo Ndegwa
Author(s): 
Daniel J. Bridges, James Bunn, Jan A. van Mourik, Georges Grau, Roger J.S. Preston, Malcolm Molyneux, Valery Combes, James S. O'Donnell, Bas de Laat, and Alister Craig
Reference: 
Blood, 18 February 2010, Pages 1472-1474 Volume. 115. No. 7

During Plasmodium falciparum malaria infections, von Willebrand factor (VWF) levels are elevated, postmortem studies show platelets colocalized with sequestered infected erythrocytes (IEs) at brain microvascular sites, whereas in vitro studies have demonstrated platelet-mediated IE adhesion to tumor necrosis factor-activated brain endothelium via a bridging mechanism.

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