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chloroquine-resistance

Open Access | Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand

May 25, 2011 - 08:52 -- Kabogo Ndegwa
Author(s): 
Rijken MJ, Boel ME, Russell B, Imwong M, Leimanis ML, Pyae Phyo A, Muehlenbachs A, Lindegardh N, McGready R, Renia L, Snounou G, Singhasivanon P, Nosten F
Reference: 
Malaria Journal 2011, 10:113 (5 May 2011)

Chloroquine (CQ) resistant vivax malaria is spreading. In this case, Plasmodium vivax infections during pregnancy and in the postpartum period were not satisfactorily cleared by CQ, despite adequate drug concentrations.

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In vitro antiplasmodial activity and cytotoxicity of crude extracts and compounds from the stem bark of Kigelia africana (Lam.) Benth (Bignoniaceae)

May 25, 2011 - 08:07 -- Kabogo Ndegwa
Author(s): 
Denis Zofou, Archile Bernabe Ouambo Kengne, Mathieu Tene, Moses N. Ngemenya, Pierre Tane and Vincent P. K. Titanji
Reference: 
Parasitology Research, Volume 108, Number 6, 1383-1390

In order to assess the potential of the stem bark of Kigelia africana (Lam.) Benth as source of new anti-malarial leads, n-hexane and ethyl acetate (EtOAc) extracts and four compounds isolated from the stem bark were screened in vitro against the chloroquine-resistant W-2 and two field isolates of Plasmodium falciparum using lactate dehydrogenase assay.

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Synthesis and in vitro antimalarial activity of tetraoxane-amine/amide conjugates

May 25, 2011 - 07:24 -- Kabogo Ndegwa
Author(s): 
Nitin Kumar, Shabana I. Khan, Himanshu Atheaya, Ritu Mamgain, Diwan S. Rawat
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 7, July 2011, Pages 2816-2827

A series of tetraoxanes, tetraoxane-amine and tetraoxane-amide conjugates have been synthesized and screened for in vitro antimalarial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.

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New ferrocenic pyrrolo[1,2-a]quinoxaline derivatives: Synthesis, and in vitro antimalarial activity – Part II

May 4, 2011 - 12:54 -- Kabogo Ndegwa
Author(s): 
Jean Guillon, Elisabeth Mouray, Philippe Grellier, et al.
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 6, June 2011, Pages 2310-2326

Following our search for antimalarial compounds, novel series of ferrocenyl-substituted pyrrolo[1,2-a]quinoxalines 1-2 were synthesized from ferrocene-carboxaldehyde and tested for their in vitro activity upon the erythrocytic development of Plasmodium falciparum strains with different chloroquine-resistance status.

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Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials

February 17, 2011 - 12:45 -- Kabogo Ndegwa
Author(s): 
S., Praveen Kumar | Jiri, Gut | Rita C., Guedes | Philip J., Rosenthal | Maria M.M., Santos | Rui, Moreira
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 3, March 2011, Pages 927-933

The design, synthesis and evaluation of 3-methylene-substituted indolinones as falcipain inhibitors and antiplasmodial agents are described.

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Plasmodium berghei K173: Selection of resistance to naphthoquine in a mouse model

January 20, 2011 - 12:05 -- Kabogo Ndegwa
Author(s): 
Hong Wang, Zhu-Chun Bei, Jing-Yan Wang, Wu-Chun Cao
Reference: 
Experimental Parasitology, Volume 127, Issue 2, February 2011, Pages 436-439

Naphthoquine (NQ), as a component of ARCO® which composed of NQ and artemisinin, is a new 4-aminoquinoline antimalarial synthesized by our institute.

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Case Report: Molecular method for the diagnosis of imported pediatric malaria

February 19, 2010 - 12:16 -- Kabogo Ndegwa
Author(s): 
L. Delhaes Jeanne, A. Berry, E. Dutoit, F. Leclerc, J. Beaudou, S. Leteurtre, D. Camus, F. Benoit-Vical
Reference: 
Médecine et Maladies Infectieuses, Volume 40, Issue 2, February 2010, Pages 115-118

We report a case of imported malaria in a boy, illustrating the epidemiological and clinical aspects of severe pediatric malaria.

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