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P. yoelii

Arrest of Nuclear Division in Plasmodium through Blockage of Erythrocyte Surface Exposed Ribosomal Protein P2

August 15, 2012 - 07:33 -- Kabogo Ndegwa
Author(s): 
Sudipta Das, Himanish Basu, Reshma Korde, Rita Tewari, Shobhona Sharma
Reference: 
PLoS Pathogens 8(8): e1002858

MalariaWorldMalaria parasites reside inside erythrocytes and the disease manifestations are linked to the growth inside infected erythrocytes (IE).

Mosquito ingestion of antibodies against mosquito midgut microbiota improves conversion of ookinetes to oocysts for Plasmodium falciparum, but not P. yoelii

November 25, 2011 - 15:01 -- Patrick Sampao
Author(s): 
Bruce H. Noden, Jefferson A. Vaughan, Charles B. Pumpuni, John C. Beier
Reference: 
Parasitology International, Volume 60, Issue 4, December 2011, Pages 440-446

MalariaWorldWhile this study highlights the complex interactions occurring between the parasite, mosquito, and midgut microbiota, the ultimate goal is to determine the influence of midgut microbiota on Plasmodium development in anopheline midguts in malaria endemic settings.

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Effect of nanoparticle coating on the immunogenicity of plasmid DNA vaccine encoding P. yoelii MSP-1 C-terminal

April 18, 2011 - 13:52 -- Patrick Sampao
Author(s): 
M.N. Shuaibu, M.S. Cherif, T. Kurosaki, G.K. Helegbe, M. Kikuchi, T. Yanagi, H. Sasaki, K. Hirayama
Reference: 
Vaccine, Volume 29, Issue 17, 12 April 2011, Pages 3239-3247

These results therefore, overall indicate the possibility of selection and optimization of DNA vaccine formulation for intravenous delivery and may be useful in designing a nanoparticle-coated DNA vaccine that could optimally elicit a desired antibody response for various disease conditions.

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Open Access | Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice

April 20, 2010 - 09:25 -- Kabogo Ndegwa
Author(s): 
Herbas MS, Ueta YY, Ichikawa C, Chiba M, Ishibashi K, Shichiri M, Fukumoto S, Yokoyama N, Takeya M, Xuan X, Arai H, Suzuki H
Reference: 
Malaria Journal 2010, 9:101 (19 April 2010)

Various factors impact the severity of malaria, including the nutritional status of the host. Vitamin E, an intra and extracellular anti-oxidant, is one such nutrient whose absence was shown previously to negatively affect Plasmodium development.

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Open Access : Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii

February 16, 2010 - 13:33 -- Ingeborg van Schayk
Author(s): 
Irosoki Eslava, Gilberto Payares, Beatriz M Pernia, Anthony A Holder, Lilian M Spencer
Reference: 
Malaria Journal 2010, 9:46 (10 February 2010)

These results suggest that a combination of protective antibodies with either the same or different isotypes can produce either an additive or a suppressive effect in passive immunization. This phenomenon may be important in better understanding immunity in this experimental mouse model of malaria.

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