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multidrug resistant

Orally active esters of dihydroartemisinin: Synthesis and antimalarial activity against multidrug-resistant Plasmodium yoelii in mice

February 13, 2010 - 11:42 -- Kabogo Ndegwa
Author(s): 
Chandan Singh, Sandeep Chaudhary and Sunil K. Puri
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 4, 15 February 2008, Pages 1436-1441

A series of artemisinin derived esters 7a–j, incorporating pharmacologically privileged substructure, such as biphenyl, adamantane and fluorene, have been prepared and evaluated for antimalarial activity against multidrug-resistant (MDR) Plasmodium yoelii nigeriensis by oral route.

Medical Condition: 
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