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P. vivax

Open Access | Evaluation of the rapid diagnostic test SDFK40 (Pf-pLDH/pan-pLDH) for the diagnosis of malaria in a non-endemic setting

January 14, 2011 - 06:32 -- Kabogo Ndegwa
Author(s): 
Maltha J, Gillet P, Cnops L, Bottieau E, Van Esbroeck M, Bruggeman C, Jacobs J
Reference: 
Malaria Journal 2011, 10:7 (12 January 2011)

SDFK40 performance was poor at low (<100/microl) parasite densities, precluding its use as the only diagnostic tool for malaria diagnosis.

Open Access | Case Report: The reality of using primaquine

December 29, 2010 - 12:01 -- Kabogo Ndegwa
Author(s): 
Burgoine K, Bancone G, Nosten F
Reference: 
Malaria Journal 2010, 9:376 (27 December 2010)

Whilst primaquine remains the drug of choice to eradicate hypnozoites and control P. vivax transmission, the risks associated with its use must be minimized during its deployment.

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Open Access | Analysis of the dihydrofolate reductase-thymidylate synthase gene sequences in Plasmodium vivax field isolates that failed chloroquine treatment

November 24, 2010 - 09:12 -- Kabogo Ndegwa
Author(s): 
Won-Ja Lee, Hyung-Hwan Kim, Yien-Kyoung Choi, Kyung-Mi Choi, Mi-A Kim, Jung-Yeon Kim, Jetsumon Sattabongkot, Youngjoo Sohn, Hyuk Kim, Jong-Koo Lee, Han-Sook Park, Hyeong-Woo Lee
Reference: 
Malaria Journal 2010, 9:331 (18 November 2010)

These results suggest that sequence variations in the DHFR-TS represent the prevalence of antifolate-resistant P. vivax in Korea.

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Open Access | Biochemical Properties of a Novel Cysteine Protease of Plasmodium vivax, Vivapain-4

October 16, 2010 - 08:38 -- Kabogo Ndegwa
Author(s): 
Byoung-Kuk Na, Young-An Bae, Young-Gun Zo, Youngchool Choe, Seon-Hee Kim, Prashant V. Desai, Mitchell A. Avery, Charles S. Craik, Tong-Soo Kim, Philip J. Rosenthal, Yoon Kong
Reference: 
PLoS Negl Trop Dis 4(10): e849

VX-4 demonstrates pH-dependent substrate switching, which might offer an efficient mechanism for the specific cleavage of different substrates in different intracellular environments. VX-4 might function as a hemoglobinase in the acidic parasite food vacuole, a maturase of P. vivax plasmepsin 4 at neutral or acidic pH, and a cytoskeleton-degrading protease in the neutral erythrocyte cytosol.

Open Access | Cost effectiveness of OptiMal(R) rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil

October 16, 2010 - 07:50 -- Kabogo Ndegwa
Author(s): 
Fernandes de Oliveira M, de Castro Gomes A, Toscano CM
Reference: 
Malaria Journal 2010, 9:277 (11 October 2010)

Microscopy is more cost-effective than OptiMal(R) in these remote areas if high accuracy of microscopy is maintained in the field. Decision regarding use of rapid tests for diagnosis of malaria in these areas depends on current microscopy accuracy in the field.

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Detection of Plasmodium falciparum, P. vivax, P. ovale, and P. malariae Merozoite Surface Protein 1-p19 Antibodies in Human Malaria Patients and Experimentally Infected Nonhuman Primates

October 4, 2010 - 09:07 -- Kabogo Ndegwa
Author(s): 
A. Scott Muerhoff, Larry G. Birkenmeyer, Ruthie Coffey, Bruce J. Dille, John W. Barnwell, William E. Collins, Joann S. Sullivan, George J. Dawson, and Suresh M. Desai
Reference: 
Clin. Vaccine Immunol. 2010;17 1631-1638

Approximately 3.2 billion people live in areas where malaria is endemic, and WHO estimates that 350 to 500 million malaria cases occur each year worldwide. This high prevalence, and the high frequency of international travel, creates significant risk for the exportation of malaria to countries where malaria is not endemic and for the introduction of malaria organisms into the blood supply.

Open Access | Modeling the effects of weather and climate change on malaria transmission

May 10, 2010 - 09:34 -- Kabogo Ndegwa
Author(s): 
PE Parham, E Michael
Reference: 
Environ Health Perspect 118:620-626

Disease emergence, extinction, and transmission all depend strongly on climate. Mathematical models offer powerful tools for understanding geographic shifts in incidence as climate changes. Nonlinear dependences of transmission on climate necessitates consideration of both changing climate trends and variability across time scales of interest.

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Open Access | Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria

February 11, 2010 - 08:36 -- Kabogo Ndegwa
Author(s): 
Quirijn de Mast, Din Syafruddin, Stephan Keijmel, Teun Olde Riekerink, Oktavian Deky, Puji B. Asih, Dorine W. Swinkels, Andre J. van der Ven
Reference: 
Haematologica, Volume 95, No. 2, February 2010

Asymptomatic Plasmodium spp. infections and anemia are highly prevalent conditions in tropical regions. We studied whether asymptomatic parasitemia induces hepcidin- and/or cytokine-mediated iron maldistribution and anemia.

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