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P. vivax

Open Access | Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria

March 22, 2012 - 12:33 -- Patrick Sampao
Author(s): 
Katarzyna KINGA Modrzynska, Alison Creasey, Paul Hunt, et al.
Reference: 
BMC Genomics 2012, 13:106

MalariaWorldTo address these questions, we investigated the genetic basis of chloroquine resistance in an isogenic lineage of rodent malaria parasite P. chabaudi in which high level resistance to chloroquine has been progressively selected under laboratory conditions.

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Open Access | Studying relationships between environment and malaria incidence in Camopi (French Guiana) through the objective selection of buffer-based landscape characterisations

December 14, 2011 - 10:50 -- Patrick Sampao
Author(s): 
Stefani A, Roux E, Fotsing J, Carme B
Reference: 
International Journal of Health Geographics 2011, 10:65 (13 December 2011)

MalariaWorldA land-cover map, the hydrological network and the geolocalised inhabited houses were used to characterise the peridomestic landscape in eleven discoid buffers with radii of 50, 100, 200, 300, 400, 500, 600, 700, 800, 900 and 1000 metres.

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Development and Evaluation of a Rapid Diagnostic Test for Plasmodium falciparum, P. vivax, and Mixed-Species Malaria Antigens.

December 9, 2011 - 08:26 -- Patrick Sampao
Author(s): 
Lee GC, Jeon ES, Le DT, Kim TS, Yoo JH, Kim HY, Chong CK.
Reference: 
Am J Trop Med Hyg. 2011 Dec;85(6):989-993.

MalariaWorldOur results showed that its sensitivities for P. falciparum, P. vivax, and mixed-species infection were 96.5%, 95.3%, and 85.7%, respectively. In addition, its specificity was high (99.4%).

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Ex Vivo Drug Susceptibility of Ferroquine against Chloroquine-Resistant Isolates of Plasmodium falciparum and P. vivax

August 18, 2011 - 15:09 -- Patrick Sampao
Author(s): 
Jutta Marfurt, Ferryanto Chalfein, Ric N. Price, et al.
Reference: 
Antimicrobial Agents and Chemotherapy, September 2011,p. 4461-4464, Vol. 55, No. 9

In the current study, ex vivo FQ activity was tested in multidrug-resistant P. falciparum and P. vivax field isolates using a schizont maturation assay.

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Open Access | Applied Genomics: Data Mining Reveals Species-Specific Malaria Diagnostic Targets More Sensitive than 18S rRNA

July 21, 2011 - 13:16 -- Patrick Sampao
Author(s): 
Allison Demas, Jenna Oberstaller, Jessica C. Kissinger, et al.
Reference: 
J. Clin. Microbiol., Jul 2011; 49: 2411 - 2418.

We show that bioinformatics approaches can be successfully applied to identify novel diagnostic targets and improve molecular methods for pathogen detection.

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Open Access | Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among Humans and Anopheles dirus Mosquitoes, Southern Vietnam

June 30, 2011 - 13:47 -- Patrick Sampao
Author(s): 
Ron P. Marchand, Richard Culleton, Yoshimasa Maeno, Nguyen Tuyen Quang, and Shusuke Nakazawa
Reference: 
EID Journal Home > Volume 17, Number 7–July 2011

These results imply that even if human malaria could be eliminated, forests that harbor An. dirus mosquitoes and macaque monkeys will remain a reservoir for the zoonotic transmission of P. knowlesi.

Open Access | Modelling the global constraints of temperature on transmission of Plasmodium falciparum and P. vivax

June 1, 2011 - 07:10 -- Patrick Sampao
Author(s): 
Gething PW, Van Boeckel TP, Smith DL, Guerra CA, Patil AP, Snow RW, Hay SI
Reference: 
Parasites & Vectors 2011, 4:92 (26 May 2011)

We defined a dynamic biological model that incorporated the principal mechanisms of temperature dependency in the malaria transmission cycle and used it with fine spatial and temporal resolution temperature data to evaluate time-series of temperature suitability for transmission of Plasmodium falciparum and P. vivax throughout an average year, quantified using an index proportional to the basic reproductive number.

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Open Access | Ex Vivo Activity of Histone Deacetylase Inhibitors against Multidrug-Resistant Clinical Isolates of Plasmodium falciparum and P. vivax

March 1, 2011 - 06:28 -- Kabogo Ndegwa
Author(s): 
Jutta Marfurt, Ferryanto Chalfein, Pak Prayoga, Frans Wabiser, Enny Kenangalem, Kim A. Piera, David P. Fairlie, Emiliana Tjitra, Nicholas M. Anstey, Kathy T. Andrews, and Ric N. Price
Reference: 
Antimicrobial Agents and Chemotherapy, March 2011, p. 961-966, Vol. 55, No. 3

Histone acetylation plays an important role in regulating gene transcription and silencing in Plasmodium falciparum.

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Azithromycin for treating uncomplicated malaria

February 22, 2011 - 07:48 -- Kabogo Ndegwa
Author(s): 
Anna M van Eijk, Dianne J Terlouw
Reference: 
Cochrane Infectious Diseases Group, Issue 2, 2011

Currently, there is no evidence for the superiority or equivalence of azithromycin monotherapy or combination therapy for the treatment of P. falciparum or P. vivax compared with other antimalarials or with the current first-line antimalarial combinations.

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Open Access | A Research Agenda for Malaria Eradication: Diagnoses and Diagnostics

January 27, 2011 - 09:57 -- Kabogo Ndegwa
Author(s): 
The malERA Consultative Group on Diagnoses and Diagnostics
Reference: 
PLoS Med 8(1): e1000396

Many of malaria's signs and symptoms are indistinguishable from those of other febrile diseases.

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