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P. falciparum

Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults

April 15, 2010 - 15:07 -- Patrick Sampao
Chintana P., Collins O., et al.
Immunogenetics, Online first

Since the role of genetic variation in conditioning severe malaria in Thai adults is largely unexplored, the functional association between IL12B polymorphisms [i.e. IL12Bpro (rs17860508) and IL12B 3′ UTR T/G (rs3212227)], severe malaria and cytokine production was examined in patients with Plasmodium falciparum infections (n = 355) recruited from malaria endemic areas along the Thai–Myanmar border in northwest Thailand.


Open Access | A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

April 15, 2010 - 12:11 -- Kabogo Ndegwa
Peter D. Crompton, Matthew A. Kayala, Susan K. Pierce,.et al
PNAS 2010 107 (15) 6958-6963

This approach, if validated in larger studies and in other epidemiological settings, could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf and for identifying previously undescribed vaccine targets.


Open Access | An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum

April 9, 2010 - 06:58 -- Patrick Sampao
Roselani I. Henry, Simon A. C., Richard J., et al
The Journal of Biological Chemistry

In this study, a combination of fluorescent ion indicators and 36Cl- flux measurements was used to investigate the transport of Cl- and the Cl- dependent transport of "H+ equivalents" in mature (trophozoite-stage) parasites, isolated from their host erythrocytes.


Open Access | Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria

February 11, 2010 - 08:36 -- Kabogo Ndegwa
Quirijn de Mast, Din Syafruddin, Stephan Keijmel, Teun Olde Riekerink, Oktavian Deky, Puji B. Asih, Dorine W. Swinkels, Andre J. van der Ven
Haematologica, Volume 95, No. 2, February 2010

Asymptomatic Plasmodium spp. infections and anemia are highly prevalent conditions in tropical regions. We studied whether asymptomatic parasitemia induces hepcidin- and/or cytokine-mediated iron maldistribution and anemia.


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