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P. falciparum

Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults

April 15, 2010 - 15:07 -- Patrick Sampao
Author(s): 
Chintana P., Collins O., et al.
Reference: 
Immunogenetics, Online first

Since the role of genetic variation in conditioning severe malaria in Thai adults is largely unexplored, the functional association between IL12B polymorphisms [i.e. IL12Bpro (rs17860508) and IL12B 3′ UTR T/G (rs3212227)], severe malaria and cytokine production was examined in patients with Plasmodium falciparum infections (n = 355) recruited from malaria endemic areas along the Thai–Myanmar border in northwest Thailand.

Country: 

Open Access | A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

April 15, 2010 - 12:11 -- Kabogo Ndegwa
Author(s): 
Peter D. Crompton, Matthew A. Kayala, Susan K. Pierce,.et al
Reference: 
PNAS 2010 107 (15) 6958-6963

This approach, if validated in larger studies and in other epidemiological settings, could prove to be a useful strategy for better understanding fundamental properties of the human immune response to Pf and for identifying previously undescribed vaccine targets.

Technology: 

Open Access | An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum

April 9, 2010 - 06:58 -- Patrick Sampao
Author(s): 
Roselani I. Henry, Simon A. C., Richard J., et al
Reference: 
The Journal of Biological Chemistry

In this study, a combination of fluorescent ion indicators and 36Cl- flux measurements was used to investigate the transport of Cl- and the Cl- dependent transport of "H+ equivalents" in mature (trophozoite-stage) parasites, isolated from their host erythrocytes.

Technology: 

Open Access | Increased serum hepcidin and alterations in blood iron parameters associated with asymptomatic P. falciparum and P. vivax malaria

February 11, 2010 - 08:36 -- Kabogo Ndegwa
Author(s): 
Quirijn de Mast, Din Syafruddin, Stephan Keijmel, Teun Olde Riekerink, Oktavian Deky, Puji B. Asih, Dorine W. Swinkels, Andre J. van der Ven
Reference: 
Haematologica, Volume 95, No. 2, February 2010

Asymptomatic Plasmodium spp. infections and anemia are highly prevalent conditions in tropical regions. We studied whether asymptomatic parasitemia induces hepcidin- and/or cytokine-mediated iron maldistribution and anemia.

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