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P. falciparum

Taste-masked quinine pamoate tablets for treatment of children with uncomplicated Plasmodium falciparum malaria

May 12, 2010 - 14:21 -- Patrick Sampao
Author(s): 
E. Kayitare, C. Vervaet, E. Mehuys, P.C. Kayumba, J.D. Ntawukulilyayo, C. Karema, Van Bortel, J.P. Remon
Reference: 
International Journal of Pharmaceutics, Volume 392, Issues 1-2, 15 June 2010, Pages 29-34

This study aimed to develop taste-masked quinine tablets suitable for children and offering dosing flexibility to adjust the quinine dose in function of body weight.

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The effect of timing and frequency of Plasmodium falciparum infection during pregnancy on the risk of low birth weight and maternal anemia

May 11, 2010 - 13:35 -- Patrick Sampao
Author(s): 
Linda Kalilani, Innocent Mofolo, Marjorie Chaponda, Stephen J. Rogerson, Steven R. Meshnick
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 6, June 2010, Pages 416-422

Birth weight and maternal hemoglobin were measured at delivery. The association between timing and frequency of infection and LBW and maternal anemia was analyzed using a binomial regression model.

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Open Access | Modeling the effects of weather and climate change on malaria transmission

May 10, 2010 - 09:34 -- Kabogo Ndegwa
Author(s): 
PE Parham, E Michael
Reference: 
Environ Health Perspect 118:620-626

Disease emergence, extinction, and transmission all depend strongly on climate. Mathematical models offer powerful tools for understanding geographic shifts in incidence as climate changes. Nonlinear dependences of transmission on climate necessitates consideration of both changing climate trends and variability across time scales of interest.

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Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimalarial Agents

May 10, 2010 - 09:29 -- Kabogo Ndegwa
Author(s): 
D Gupta, RS Yedidi, S Varghese, LC Kovari, PM Woster
Reference: 
J Med Chem May 3, 2010

Four aspartyl proteases known as plasmepsins are involved in the degradation of hemoglobin by Plasmodium falciparum, which causes a large percentage of malaria deaths. The enzyme plasmepsin II (PlmII) is the most extensively studied of these aspartyl proteases and catalyzes the initial step in the breakdown of hemoglobin by the parasite.

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Open Access | Beneficial effect of aurothiomalate on murine malaria

May 10, 2010 - 08:56 -- Kabogo Ndegwa
Author(s): 
Alesutan I, Bobbala D, Qadri SM, Estremera A, Foller M, Lang F
Reference: 
Malaria Journal 2010, 9:118 (7 May 2010)

Sodium aurothiomalate influences the survival of Plasmodium berghei-infected mice, an effect only partially explained by stimulation of eryptosis.

High prevalence of sulfadoxine/pyrimethamine resistance alleles in Plasmodium falciparum parasites from Bangladesh

May 5, 2010 - 08:10 -- Patrick Sampao
Author(s): 
Aung Swi Prue Marma, Toshihiro Mita, Hideaki Eto, Takahiro Tsukahara, Sumon Sarker, Hiroyoshi Endo
Reference: 
Parasitology International, Volume 59, Issue 2, June 2010, Pages 178-182

To assess the distribution of pfcrt, pfmdr1, dhfr, and dhps genotypes in Plasmodium falciparum, we conducted hospital- and community-based surveys in Bandarban, Bangladesh (near the border with Myanmar) in 2007 and 2008.

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Plasmodium falciparum Dihydrofolate Reductase and Dihyropteroate Synthase Mutations and the Use of Trimethoprim-Sulfamethoxazole Prophylaxis among Persons Infected with Human Immunodeficiency Virus

May 4, 2010 - 14:19 -- Patrick Sampao
Author(s): 
Samuel Malamba, Taylor Sandison, John Lule, Arthur Reingold, Jordan Walker, Grant Dorsey, AND Jonathan Mermin
Reference: 
Am J Trop Med Hyg, May 2010; 82: 766 - 771.

Although resistance rates of P. falciparum to antifolate drugs are high, cotrimoxazole-prophylaxis in HIV-infected persons was not associated with a higher prevalence of mutations associated with antifolate resistance. 

Plasmodium falciparum PF10_0164 (ETRAMP10.3) Is an Essential Parasitophorous Vacuole and Exported Protein in Blood Stages

May 4, 2010 - 09:46 -- Patrick Sampao
Author(s): 
Drew C. MacKellar, Matthew T. O'Neill, Ahmed S. I. Aly, John B. Sacci, Jr., Alan F. Cowman, and Stefan H. I. Kappe
Reference: 
Eukaryot. Cell, May 2010; 9: 784 - 794.

We show that PF10_0164 is expressed in sporozoites and blood stages of P. falciparum, where it localizes to the parasitophorous vacuole, and is also exported to the host erythrocyte. PF10_0164 is refractory to disruption in asexual blood stages.

Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition

May 4, 2010 - 08:13 -- Patrick Sampao
Author(s): 
Ping Wang, Qi Wang, Yonghong Yang, James K. Coward, Alexis Nzila, Paul F.G. Sims, John E. Hyde
Reference: 
Molecular and Biochemical Parasitology, Volume 172, Issue 1, July 2010, Pages 41-51

Unusually for a eukaryote, the malaria parasite Plasmodium falciparum expresses dihydrofolate synthase (DHFS) and folylpolyglutamate synthase (FPGS) as a single bifunctional protein. The two activities contribute to the essential pathway of folate biosynthesis and modification.

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The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus

May 3, 2010 - 15:27 -- Patrick Sampao
Author(s): 
Dayadevi Jirage, Yueqin Chen, Diana Caridha, Michael T. O’Neil, Fredrick Eyase, William H. Witola, Choukri Ben Mamoun, Norman C. Waters
Reference: 
Molecular and Biochemical Parasitology, Volume 172, Issue 1, July 2010, Pages 9-18

We demonstrate that that these two proteins are substrates of Pfmrk-mediated phosphorylation and that PfMAT1 confers substrate specificity to the Pfmrk kinase complex.

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