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P. falciparum

Open Access | Chloroquine Clinical Failures in P. falciparum Malaria Are Associated with Mutant Pfmdr-1, Not Pfcrt in Madagascar

October 17, 2010 - 14:45 -- Patrick Sampao
Author(s): 
Valérie A., Arsène R., et al.
Reference: 
PLoS ONE 5(10) e13281

These results highlight the limits of the current in vitro tests routinely used to monitor CQ drug resistance in this unique context. Gaining insight about the mechanisms that regulate polymorphism in Pfmdr1 remains important, particularly regarding the evolution and spread of Pfmdr-1 alleles in P. falciparum populations under changing drug pressure which may have important consequences in terms of antimalarial use management.

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Open Access | Cost effectiveness of OptiMal(R) rapid diagnostic test for malaria in remote areas of the Amazon Region, Brazil

October 16, 2010 - 07:50 -- Kabogo Ndegwa
Author(s): 
Fernandes de Oliveira M, de Castro Gomes A, Toscano CM
Reference: 
Malaria Journal 2010, 9:277 (11 October 2010)

Microscopy is more cost-effective than OptiMal(R) in these remote areas if high accuracy of microscopy is maintained in the field. Decision regarding use of rapid tests for diagnosis of malaria in these areas depends on current microscopy accuracy in the field.

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Open Access | Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai-Myanmar border

October 13, 2010 - 09:19 -- Kabogo Ndegwa
Author(s): 
Na-Bangchang K, Ruengweerayut R, Mahamad P, Ruengweerayut K, Chaijaroenkul W
Reference: 
Malaria Journal 2010, 9:273 (8 October 2010)

Although pharmacokinetic (ethnic-related) factors including resistance of P. falciparum to mefloquine contribute to some treatment failure following treatment with a three-day combination regimen of artesunate-mefloquine, results suggest that artesunate resistance may be emerging at the Thai-Myanmar border.

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Open Access | Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology

October 11, 2010 - 08:15 -- Kabogo Ndegwa
Author(s): 
Ballif M, Hii J, Marfurt J, Crameri A, Fafale A, Felger I, Beck H, Genton B
Reference: 
Malaria Journal 2010, 9:270 (6 October 2010)

This work provides the first insight into drug resistance markers of P. falciparum in the SI. The obtained results indicated the presence of a very homogenous P. falciparum population circulating in the community.

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Open Access | Sequestration and Tissue Accumulation of Human Malaria Parasites: Can We Learn Anything from Rodent Models of Malaria?

October 6, 2010 - 08:09 -- Kabogo Ndegwa
Author(s): 
Blandine Franke-Fayard, Jannik Fonager, Anneke Braks, Shahid M. Khan, Chris J. Janse
Reference: 
PLoS Pathog 6(9): e1001032

The sequestration of Plasmodium falciparum–infected red blood cells (irbcs) in the microvasculature of organs is associated with severe disease; correspondingly, the molecular basis of irbc adherence is an active area of study.

Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte

September 14, 2010 - 07:31 -- Patrick Sampao
Author(s): 
Simone K., Melanie R., et al.
Reference: 
Cellular Microbiology, Vol 12, Issue 10, pg 1398–1420, Oct 2010

Here, we have generated transfectant lines expressing GFP- or HA-Strep-tagged versions of these proteins, and used these to investigate both localization and other properties of these Hsp40 co-chaperones.

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3D structure determination of STARP peptides implicated in P. falciparum invasion of hepatic cells

July 21, 2010 - 07:22 -- Patrick Sampao
Author(s): 
Adriana Bermúdez, Martha Patricia Alba, Magnolia Vanegas, Manuel Elkin Patarroyo
Reference: 
Vaccine, Volume 28, Issue 31, 12 July 2010, Pages 4989-4996

This study shows the results of immunization trials in Aotus monkeys with native STARP peptides and analogues modified in critical hepatic-cell binding residues.

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Open Access | Estimating the Number of Paediatric Fevers Associated with Malaria Infection Presenting to Africa's Public Health Sector in 2007

July 8, 2010 - 07:58 -- Kabogo Ndegwa
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Author(s): 
Peter W. Gething, Viola C. Kirui, Victor A. Alegana, Emelda A. Okiro, Abdisalan M. Noor, Robert W. Snow
Reference: 
PLoS Med 7(7): e1000301

Spatial estimates of childhood fevers and care-seeking rates can be combined with a relational risk model of infection prevalence in the community to estimate the degree of parasitemia in those fevers reaching public health facilities.

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Open Access | Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

May 25, 2010 - 12:19 -- Kabogo Ndegwa
Author(s): 
Bousema T, Okell L, Shekalaghe S, Griffin JT, Omar S, Sawa P, Sutherland C, Sauerwein R, Ghani AC, Drakeley C
Reference: 
Malaria Journal 2010, 9:136 (24 May 2010)

These findings confirm previous estimates of the circulation time of gametocytes, but indicate a much longer duration of (low density) gametocyte carriage after apparently successful clearance of asexual parasites.

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Short Communication: Complementation of Saccharomyces cerevisiae pik1ts by a phosphatidylinositol 4-kinase from Plasmodium falciparum

May 21, 2010 - 08:18 -- Patrick Sampao
Author(s): 
Tim Krüger, Cecilia P. Sanchez, Michael Lanzer
Reference: 
Molecular and Biochemical Parasitology, Volume 172, Issue 2, August 2010, Pages 149-151

Our data show that the corresponding P. falciparum gene, termed PFE0485w, can functionally complement a yeast temperature-sensitive pik1 mutation.

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