Currently, there is no evidence for the superiority or equivalence of azithromycin monotherapy or combination therapy for the treatment of P. falciparum or P. vivax compared with other antimalarials or with the current first-line antimalarial combinations.
Adult P. falciparum prevalence is substantial in the DRC and is associated with under-5 mortality.
A novel class of hybrid 4-anilinoquinoline triazines have been synthesized and evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of P. falciparum as well as for their cytotoxicity toward VERO cell line.
The health district of Ouidah-Kpomasse-Tori Bossito is a mesoendemic area with a moderate level of pyrethroid-resistance of vectors.
A molecular docking study was carried out on 28 compounds belonging to 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs using Glide, FlexX and GOLD programs and the X-ray crystallographic structures of the quadruple mutant (1J3K:pdb) and wild type (1J3I:pdb) Plasmodium falciparum dihydrofolate reductase enzyme.
The intensity of the contacts with P. falciparum seems to represent the main factor influencing anti-schizont IgG responses.
Here, we studied the dynamics of and requirements for in vitro NK responses to PfRBC in malaria-naïve volunteers undergoing a single experimental malaria infection under highly controlled circumstances, and in naturally exposed individuals. NK-specific IFN-γ responses to PfRBC following exposure resembled an immunological recall pattern and were tightly correlated with T-cell responses.
With regard to malaria, a major selective force in recent human evolution, protective erythrocyte variants have been describe, but little is known as to their possible impact on the transmission of the parasite from the human host to the Anopheles vector.
Understanding the mechanism behind this specific CSA interaction is important for the optimal design of a vaccine against placental malaria.
These results support the notion that unique selective pressure on the TNF/LTA/LTB locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility.