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P. falciparum

Azithromycin for treating uncomplicated malaria

February 22, 2011 - 07:48 -- Kabogo Ndegwa
Author(s): 
Anna M van Eijk, Dianne J Terlouw
Reference: 
Cochrane Infectious Diseases Group, Issue 2, 2011

Currently, there is no evidence for the superiority or equivalence of azithromycin monotherapy or combination therapy for the treatment of P. falciparum or P. vivax compared with other antimalarials or with the current first-line antimalarial combinations.

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Open Access | Molecular Malaria Epidemiology: Mapping and Burden Estimates for the Democratic Republic of the Congo, 2007

February 7, 2011 - 08:12 -- Kabogo Ndegwa
Author(s): 
Steve M. Taylor, Jane P. Messina, Carla C. Hand, Jonathan J. Juliano, Jeremie Muwonga, Antoinette K. Tshefu, Benjamin Atua, Michael Emch, Steven R. Meshnick
Reference: 
PLoS ONE 6(1): e16420

Adult P. falciparum prevalence is substantial in the DRC and is associated with under-5 mortality.

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4-Anilinoquinoline triazines: A novel class of hybrid antimalarial agents

January 25, 2011 - 08:55 -- Kabogo Ndegwa
Author(s): 
Ashok, Kumar | Kumkum, Srivastava | S., Raja Kumar | M.I., Siddiqi | Sunil K., Puri | Jitendra K., Sexana | Prem M.S., Chauhan
Reference: 
European Journal of Medicinal Chemistry, Volume 46, Issue 2, February 2011, Pages 676-690

A novel class of hybrid 4-anilinoquinoline triazines have been synthesized and evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of P. falciparum as well as for their cytotoxicity toward VERO cell line.

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Open Access | Malaria infection and disease in an area with pyrethroid-resistant vectors in southern Benin

January 4, 2011 - 12:51 -- Kabogo Ndegwa
Author(s): 
Damien GB, Djenontin A, Rogier C, Corbel V, Bangana SB, Chandre F, Akogbeto M, Kinde-Gazard D, Massougbodji A, Henry M
Reference: 
Malaria Journal 2010, 9:380 (31 December 2010)

The health district of Ouidah-Kpomasse-Tori Bossito is a mesoendemic area with a moderate level of pyrethroid-resistance of vectors.

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Open Access | Binding modes of 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs to P. falciparum dihydrofolate reductase enzyme: Molecular docking studies

January 3, 2011 - 08:57 -- Kabogo Ndegwa
Author(s): 
L Adane, PV Bharatam
Reference: 
Indian Journal of Pharmaceutical Sciences ,2010, Volume: 72. Issue: 3, Page: 324-333

A molecular docking study was carried out on 28 compounds belonging to 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs using Glide, FlexX and GOLD programs and the X-ray crystallographic structures of the quadruple mutant (1J3K:pdb) and wild type (1J3I:pdb) Plasmodium falciparum dihydrofolate reductase enzyme.

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Open Access | Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children

December 20, 2010 - 12:55 -- Kabogo Ndegwa
Author(s): 
Boulanger D, Sarr J, Fillol F, Sokhna C, Cisse B, Schacht A, Trape J, Riveau G, Simondon F, Greenwood B, Remoue F
Reference: 
Malaria Journal 2010, 9:363 (17 December 2010)

The intensity of the contacts with P. falciparum seems to represent the main factor influencing anti-schizont IgG responses.

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Memory-like IFN- response by NK cells following malaria infection reveals the crucial role of T cells in NK cell activation by P. falciparum

November 26, 2010 - 13:21 -- Patrick Sampao
Author(s): 
Matthew B. B. McCall., Meta Roestenberg., Robert W. Sauerwein., et al.
Reference: 
European Journal of Immunology, Volume 40, Issue 12, pages 3472–3477, December 2010

Here, we studied the dynamics of and requirements for in vitro NK responses to PfRBC in malaria-naïve volunteers undergoing a single experimental malaria infection under highly controlled circumstances, and in naturally exposed individuals. NK-specific IFN-γ responses to PfRBC following exposure resembled an immunological recall pattern and were tightly correlated with T-cell responses.

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Open Access | Oral Presentation: Impact of protective haemoglobins C and S on P. falciparum malaria transmission in endemic area

November 8, 2010 - 09:46 -- Patrick Sampao
Author(s): 
Louis C Gouagna, Germana Bancone, Frank Yao, Carlo Costantini, Jean-Bosco Ouedraogo, David Modiano
Reference: 
Malaria Journal 2010, 9(Suppl 2):O17 (20 October 2010)

With regard to malaria, a major selective force in recent human evolution, protective erythrocyte variants have been describe, but little is known as to their possible impact on the transmission of the parasite from the human host to the Anopheles vector.

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Open Access | Invited Speaker Presentation: Structure function analysis of P. falciparum VAR2CSA

November 3, 2010 - 12:45 -- Patrick Sampao
Author(s): 
Madeleine Dahlbäck, Lars M Jørgensen, Stig Christoffersen, Morten A Nielsen, Thor G Theander, David E Arnot, Sine Larsen, Ali Salanti
Reference: 
Malaria Journal 2010, 9(Suppl 2):I4 (20 October 2010)

Understanding the mechanism behind this specific CSA interaction is important for the optimal design of a vaccine against placental malaria.

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Open Access | A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland Papuan children and adults

November 3, 2010 - 06:48 -- Kabogo Ndegwa
Author(s): 
Randall LM, Kenangalem E, Engwerda CR, et al.
Reference: 
Malaria Journal 2010, 9:302 (29 October 2010)

These results support the notion that unique selective pressure on the TNF/LTA/LTB locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility.

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