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P. falciparum

Open Access | Studying relationships between environment and malaria incidence in Camopi (French Guiana) through the objective selection of buffer-based landscape characterisations

December 14, 2011 - 10:50 -- Patrick Sampao
Author(s): 
Stefani A, Roux E, Fotsing J, Carme B
Reference: 
International Journal of Health Geographics 2011, 10:65 (13 December 2011)

MalariaWorldA land-cover map, the hydrological network and the geolocalised inhabited houses were used to characterise the peridomestic landscape in eleven discoid buffers with radii of 50, 100, 200, 300, 400, 500, 600, 700, 800, 900 and 1000 metres.

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Can we depend on case management to prevent re-establishment of P. falciparum malaria, after local interruption of transmission?

December 7, 2011 - 14:35 -- Patrick Sampao
Author(s): 
Valerie Crowell, Diggory Hardy, Olivier Briët, Nakul Chitnis, Nicolas Maire, Thomas Smith
Reference: 
Epidemics, Volume 4, Issue 1, March 2012, Pages 1-8

MalariaWorldWe assess, through mathematical modeling and simulation, which levels of case detection and treatment (case management) are required to prevent re-establishment of transmission of P. falciparum after local interruption of transmission has been achieved, in settings with varying receptivity and vulnerability.

Open Access | Applied Genomics: Data Mining Reveals Species-Specific Malaria Diagnostic Targets More Sensitive than 18S rRNA

July 21, 2011 - 13:16 -- Patrick Sampao
Author(s): 
Allison Demas, Jenna Oberstaller, Jessica C. Kissinger, et al.
Reference: 
J. Clin. Microbiol., Jul 2011; 49: 2411 - 2418.

We show that bioinformatics approaches can be successfully applied to identify novel diagnostic targets and improve molecular methods for pathogen detection.

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Open Access | Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among Humans and Anopheles dirus Mosquitoes, Southern Vietnam

June 30, 2011 - 13:47 -- Patrick Sampao
Author(s): 
Ron P. Marchand, Richard Culleton, Yoshimasa Maeno, Nguyen Tuyen Quang, and Shusuke Nakazawa
Reference: 
EID Journal Home > Volume 17, Number 7–July 2011

These results imply that even if human malaria could be eliminated, forests that harbor An. dirus mosquitoes and macaque monkeys will remain a reservoir for the zoonotic transmission of P. knowlesi.

Open Access | Engineered Resistance to Plasmodium falciparum Development in Transgenic Anopheles stephensi

April 27, 2011 - 11:35 -- Kabogo Ndegwa
Author(s): 
Alison T. Isaacs, Fengwu Li, Nijole Jasinskiene, Xiaoguang Chen, Xavier Nirmala, Osvaldo Marinotti, Joseph M. Vinetz, Anthony A. James
Reference: 
PLoS Pathog 7(4): e1002017

Transgenic mosquito lines expressing each of the scFv genes had significantly lower infection levels than controls when challenged with P. falciparum.

Open Access | Grand Rounds: The Opportunity for and Challenges to Malaria Eradication

April 26, 2011 - 14:50 -- Patrick Sampao
Author(s): 
KE Mace, PhD,* MF Lynch, MD, JR MacArthur, MD, SP Kachur, MD, L Slutsker, MD
Reference: 
Morbidity and Mortality Weekly Report (MMWR), April 22, 2011 / 60(15);476-480

These reports are based on grand rounds presentations at CDC on high-profile issues in public health science, practice, and policy.

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Immunogenicity and in vitro protective efficacy of recombinant Mycobacterium bovis bacille Calmette Guerin (rBCG) expressing the 19 kDa merozoite surface protein-1 (MSP-119) antigen of Plasmodium falciparum

March 22, 2011 - 11:26 -- Kabogo Ndegwa
Author(s): 
Asma Abdullah Nurul & Mohd Nor Norazmi
Reference: 
Parasitology Research, Volume 108, Number 4, 887-897

Vaccine development against the blood-stage malaria parasite is aimed at reducing the pathology of the disease.

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Daily survival and human blood index of major malaria vectors associated with oil palm cultivation in Cameroon and their role in malaria transmission

March 17, 2011 - 08:45 -- Kabogo Ndegwa
Author(s): 
M. C. Tanga, W. I. Ngundu and P.D. Tchouassi
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 4, pages 447–457, April 2011

Any vector control strategy intending to significantly reduce the malaria burden in the palm estate will have to take into account entomological heterogeneity in addition to ecological and socio-economic multiplicity.

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Open Access | Exceptional Diversity, Maintenance of Polymorphism, and Recent Directional Selection on the APL1 Malaria Resistance Genes of Anopheles gambiae

March 11, 2011 - 08:32 -- Kabogo Ndegwa
Author(s): 
Susan M. Rottschaefer, Michelle M. Riehle, Boubacar Coulibaly, Madjou Sacko, Oumou Niaré, Isabelle Morlais, Sekou F. Traoré, Kenneth D. Vernick, Brian P. Lazzaro
Reference: 
PLoS Biol 9(3): e1000600

The three-gene APL1 locus encodes essential components of the mosquito immune defense against malaria parasites.

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Open Access | Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure

March 9, 2011 - 08:26 -- Kabogo Ndegwa
Author(s): 
Codd A, Teuscher F, Kyle DE, Cheng Q, Gatton ML
Reference: 
Malaria Journal 2011, 10:56 (8 March 2011)

Although further studies are required to confirm dormancy in vivo, this theoretical study adds support for the hypothesis, highlighting the potential role of this parasite sub-population in treatment failure following monotherapy and reinforcing the importance of using ART in combination with other anti-malarials.

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