A land-cover map, the hydrological network and the geolocalised inhabited houses were used to characterise the peridomestic landscape in eleven discoid buffers with radii of 50, 100, 200, 300, 400, 500, 600, 700, 800, 900 and 1000 metres.
We assess, through mathematical modeling and simulation, which levels of case detection and treatment (case management) are required to prevent re-establishment of transmission of P. falciparum after local interruption of transmission has been achieved, in settings with varying receptivity and vulnerability.
We show that bioinformatics approaches can be successfully applied to identify novel diagnostic targets and improve molecular methods for pathogen detection.
These results imply that even if human malaria could be eliminated, forests that harbor An. dirus mosquitoes and macaque monkeys will remain a reservoir for the zoonotic transmission of P. knowlesi.
Transgenic mosquito lines expressing each of the scFv genes had significantly lower infection levels than controls when challenged with P. falciparum.
These reports are based on grand rounds presentations at CDC on high-profile issues in public health science, practice, and policy.
Vaccine development against the blood-stage malaria parasite is aimed at reducing the pathology of the disease.
Any vector control strategy intending to significantly reduce the malaria burden in the palm estate will have to take into account entomological heterogeneity in addition to ecological and socio-economic multiplicity.
The three-gene APL1 locus encodes essential components of the mosquito immune defense against malaria parasites.
Although further studies are required to confirm dormancy in vivo, this theoretical study adds support for the hypothesis, highlighting the potential role of this parasite sub-population in treatment failure following monotherapy and reinforcing the importance of using ART in combination with other anti-malarials.