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P. falciparum

Evaluation of the rapid diagnostic test CareStart pLDH Malaria (Pf-pLDH/pan-pLDH) for the diagnosis of malaria in a reference setting

June 20, 2012 - 12:51 -- Kabogo Ndegwa
Author(s): 
Heutmekers M, Gillet P, Maltha J, Scheirlinck A, Cnops L, Bottieau E, Van Esbroeck M, Jacobs J
Reference: 
Malaria Journal 2012, 11:204 (18 June 2012)

MalariaWorldCareStart pLDH performed excellent for the detection of P. falciparum, well for P. vivax, but poor for P. ovale and P. malariae.

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Antimalarial Activity and Mechanisms of Action of Two Novel 4-Aminoquinolines against Chloroquine-Resistant Parasites

May 30, 2012 - 06:13 -- Kabogo Ndegwa
Author(s): 
Anna Caroline Campos Aguiar, Raquel de Meneses Santos, Flávio Júnior Barbosa Figueiredo, Wilian Augusto Cortopassi, André Silva Pimentel, Tanos Celmar Costa França, Mario Roberto Meneghetti, Antoniana Ursine Krettli
Reference: 
PLoS ONE 7(5): e37259

MalariaWorldChloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or therapeutic index).

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Open Access | Differential Plasmodium falciparum infection of Anopheles gambiae s.s. molecular and chromosomal forms in Mali

May 2, 2012 - 14:31 -- Kabogo Ndegwa
Author(s): 
Trout Fryxell RT, Nieman CC, Fofana A, Lee Y, Traoré SF, Cornel AJ, Luckhart S, Lanzaro GC
Reference: 
Malaria Journal 2012, 11:133 (27 April 2012)

MalariaWorldIn this collection, the prevalence of P. falciparum infection in the M form was equivalent to infection in the S form (no molecular form differential infection).

Open Access | Survey for asymptomatic malaria cases in low transmission settings of Iran under elimination programme

May 2, 2012 - 08:23 -- Kabogo Ndegwa
Author(s): 
Zoghi S, Mehrizi AA, Raeisi A, Haghdoost AA, Turki H, Safari R, Ahmadi Kahanali A, Zakeri S
Reference: 
Malaria Journal 2012, 11:126 (25 April 2012)

MalariaWorldTaken together, the lack of asymptomatic carrier with the evidence of extremely low seropositive to both P. vivax and P. falciparum among examined individuals supported the limited recent transmission in the studied areas and, therefore, these parts of Iran have potential to eliminate the disease in the next few years.

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Open Access | Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria

March 22, 2012 - 12:33 -- Patrick Sampao
Author(s): 
Katarzyna KINGA Modrzynska, Alison Creasey, Paul Hunt, et al.
Reference: 
BMC Genomics 2012, 13:106

MalariaWorldTo address these questions, we investigated the genetic basis of chloroquine resistance in an isogenic lineage of rodent malaria parasite P. chabaudi in which high level resistance to chloroquine has been progressively selected under laboratory conditions.

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Is benign tertian malaria actually benign?

March 22, 2012 - 12:23 -- Patrick Sampao
Author(s): 
Atul Gogia, Atul Kakar and S P Byotra
Reference: 
Trop Doct April 2012 vol. 42 no. 2 92-93

MalariaWorldThis retrospective study was conducted in order to determine the incidence of various complications of Plasmodium vivax malaria based on a review of case records in a tertiary care hospital in New Delhi, India.

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Short Report: Efficacy of Artemether-Lumefantrine in Area of High Malaria Endemicity in India and Its Correlation with Blood Concentration of Lumefantrine

March 9, 2012 - 13:45 -- Patrick Sampao
Author(s): 
Neena Valecha, Suman Mohanty, Prakriti Srivastava, Surya Sharma, Prajesh Tyagi, Yngve Bergqvist and Pascal Ringwald
Reference: 
Am J Trop Med Hyg 2012 86:395-397

MalariaWorldThis study was conducted to correlate blood concentrations of lumefantrine with treatment outcome for patients with Plasmodium falciparum malaria when the drug was given without specific instructions for administration with food.

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Short Report: Different Patterns of pfcrt and pfmdr1 Polymorphisms in P. falciparum Isolates from Nigeria and Brazil: The Potential Role of Antimalarial Drug Selection Pressure

February 3, 2012 - 14:08 -- Patrick Sampao
Author(s): 
Grace O. Gbotosho, Onikepe A. Folarin, Christian T. Happi, et al.
Reference: 
Am J Trop Med Hyg 2012 86:211-213

MalariaWorldWe provide first evidence of emergence of the CVMNT haplotype in West Africa. The high prevalence of pfcrt CVIET and SVMNT haplotypes in Nigeria and Brazil, respectively, is indicative of different selective pressure by chloroquine and amodiaquine.

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The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

December 23, 2011 - 12:57 -- Patrick Sampao
Author(s): 
Alexander D. Douglas, Andrew R. Williams, Simon J. Draper, et al.
Reference: 
Nature Communications, Volume: 2 Article number: 601

MalariaWorldWe show that the full-length P. falciparum reticulocyte-binding protein homologue 5 (PfRH5) is highly susceptible to cross-strain neutralizing vaccine-induced antibodies, out-performing all other antigens delivered by the same vaccine platform.

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Open Access | Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya

December 15, 2011 - 15:05 -- Patrick Sampao
Author(s): 
Asito AS, Piriou E, Jura WG, Ouma C, Odada PS, Ogola S, Fiore N, Rochford R
Reference: 
Malaria Journal 2011, 10:362 (13 December 2011)

MalariaWorldThese data suggest that infants living in malaria endemic regions have altered B cell subset distribution.

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