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P. falciparum

Low risk of recurrence following artesunate–Sulphadoxine–pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan

March 19, 2018 - 15:48 -- Open Access
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Author(s): 
Muzamil Mahdi Abdel Hamid, Kamala Thriemer, Benedikt Ley, et al.
Reference: 
Malaria Journal 2018 17:117, 16 March 2018

AS/SP remains effective for the treatment of P. falciparum and P. vivax.

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In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate

February 6, 2017 - 15:42 -- Open Access
Author(s): 
Fabian Baumgärtner, Joëlle Jourdan, Christian Scheurer, Benjamin Blasco, Brice Campo, Pascal Mäser and Sergio Wittlin
Reference: 
Malaria Journal 2017 16:45, 25 January 2017

The absence of in vitro cross-resistance against the artemisinin-resistant clinical isolate Cam3.IR539T suggests that ozonides could be effective against artemisinin-resistant P. falciparum.

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Transfusion-transmitted malaria: donor prevalence of parasitaemia and a survey of healthcare workers knowledge and practices in a district hospital in Ghana

April 23, 2016 - 16:16 -- Open Access
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Author(s): 
Alex Owusu-Ofori, Dominic Gadzo and Imelda Bates
Reference: 
Malaria Journal 2016 15:234, 23 April 2016

The prevalence of P. falciparum parasitaemia is 10 % in healthy blood donors in the Akatsi district and represents a risk for TTM though the extent of this risk is unclear.

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Decreased prevalence of Plasmodium falciparum resistance markers to amodiaquine despite its wide scale use as ACT partner drug in Zanzibar

September 13, 2012 - 13:22 -- Kabogo Ndegwa
Author(s): 
Fröberg G, Jörnhagen L, Morris U, Shakely D, Msellem MI, Gil JP, Björkman A, Mårtensson A
Reference: 
Malaria Journal 2012, 11:321 (11 September 2012)

MalariaWorldThis is the first observation of a decreased prevalence of pfcrt 76T, pfmdr1 86Y, 184Y and 1246Y in an African setting after several years of extensive ASAQ use as first-line treatment for uncomplicated malaria.

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NOT Open Access | Various pfcrt and pfmdr1 Genotypes of Plasmodium falciparum Cocirculate with P. malariae, P. ovale spp., and P. vivax in Northern Angola

September 13, 2012 - 12:35 -- Kabogo Ndegwa
Author(s): 
Cláudia Fançony, Dina Gamboa, Yuri Sebastião, Rachel Hallett, Colin Sutherland, José Carlos Sousa-Figueiredo, and Susana Vaz Nery
Reference: 
Antimicrob. Agents Chemother. October 2012 vol. 56 no. 10 5271-5277

MalariaWorldArtemisinin-based combination therapy for malaria has become widely available across Africa.

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NOT Open Access | Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro

August 22, 2012 - 06:43 -- Kabogo Ndegwa
Author(s): 
Fabián E. Sáenz, Tina Mutka, Kenneth Udenze, Ayoade M. J. Oduola, and Dennis E. Kyle
Reference: 
Antimicrob. Agents Chemother. September 2012 vol. 56 no. 9 4685-4692

MalariaWorldNew drugs to treat malaria must act rapidly and be highly potent against asexual blood stages, well tolerated, and affordable to residents of regions of endemicity.

NOT Open Access | Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India

July 26, 2012 - 12:03 -- Kabogo Ndegwa
Author(s): 
Chinnaperumal Kamaraj, Naveen Kumar Kaushik, Dinesh Mohanakrishnan, Gandhi Elango, Asokan Bagavan, Abdul Abduz Zahir, Abdul Abdul Rahuman & Dinkar Sahal
Reference: 
Parasitology Research, Volume 111, Number 2 (2012), 703-715

In the present study, we found that 129S1 mice are resistant to the infection with Plasmodium yoelii 17XL, which is highly virulent and causes lethal infection in various strains of mice.The emergence and spread of Plasmodium falciparum with resistance to chloroquine (CQ), the safest and cheapest anti-malarial drug, coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the urgent need to tap the potential of plants for novel anti-malarials.

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Evaluation of the rapid diagnostic test CareStart pLDH Malaria (Pf-pLDH/pan-pLDH) for the diagnosis of malaria in a reference setting

June 20, 2012 - 12:51 -- Kabogo Ndegwa
Author(s): 
Heutmekers M, Gillet P, Maltha J, Scheirlinck A, Cnops L, Bottieau E, Van Esbroeck M, Jacobs J
Reference: 
Malaria Journal 2012, 11:204 (18 June 2012)

MalariaWorldCareStart pLDH performed excellent for the detection of P. falciparum, well for P. vivax, but poor for P. ovale and P. malariae.

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Antimalarial Activity and Mechanisms of Action of Two Novel 4-Aminoquinolines against Chloroquine-Resistant Parasites

May 30, 2012 - 06:13 -- Kabogo Ndegwa
Author(s): 
Anna Caroline Campos Aguiar, Raquel de Meneses Santos, Flávio Júnior Barbosa Figueiredo, Wilian Augusto Cortopassi, André Silva Pimentel, Tanos Celmar Costa França, Mario Roberto Meneghetti, Antoniana Ursine Krettli
Reference: 
PLoS ONE 7(5): e37259

MalariaWorldChloroquine (CQ) is a cost effective antimalarial drug with a relatively good safety profile (or therapeutic index).

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