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P. falciparum

Resurrection of the ancestral RH5 invasion ligand provides a molecular explanation for the origin of P. falciparum malaria in humans

October 28, 2019 - 16:19 -- Open Access
Author(s): 
Francis Galaway, Ryan Yu, Anastasia Constantinou, Franck Prugnolle, Gavin J. Wright
Reference: 
PLoS Biol 17(10): e3000490

Many important infectious diseases are the result of zoonoses, in which pathogens that normally infect animals acquire mutations that enable the breaching of species barriers to permit the infection of humans.

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DNA recovery from archived RDTs for genetic characterization of Plasmodium falciparum in a routine setting in Lambaréné, Gabon

October 7, 2019 - 15:28 -- Open Access
Author(s): 
The Trong Nguyen, Brice Nzigou Mombo, Ghyslain Mombo-Ngoma, et al.
Reference: 
Malaria Journal 2019 18:336, 2 October 2019

Rapid diagnostic tests (RDTs) have been described as a source of genetic material to analyse malaria parasites in proof-of-concept studies. The increasing use of RDTs (e.g., in focal or mass screening and treatment campaigns) makes this approach particularly attractive for large-scale investigations of parasite populations. In this study, the complexity of Plasmodium falciparum infections, parasite load and chloroquine resistance transporter gene mutations were investigated in DNA samples extracted from positive RDTs, obtained in a routine setting and archived at ambient temperature.

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Low risk of recurrence following artesunate–Sulphadoxine–pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan

March 19, 2018 - 15:48 -- Open Access
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Author(s): 
Muzamil Mahdi Abdel Hamid, Kamala Thriemer, Benedikt Ley, et al.
Reference: 
Malaria Journal 2018 17:117, 16 March 2018

AS/SP remains effective for the treatment of P. falciparum and P. vivax.

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In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate

February 6, 2017 - 15:42 -- Open Access
Author(s): 
Fabian Baumgärtner, Joëlle Jourdan, Christian Scheurer, Benjamin Blasco, Brice Campo, Pascal Mäser and Sergio Wittlin
Reference: 
Malaria Journal 2017 16:45, 25 January 2017

The absence of in vitro cross-resistance against the artemisinin-resistant clinical isolate Cam3.IR539T suggests that ozonides could be effective against artemisinin-resistant P. falciparum.

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Transfusion-transmitted malaria: donor prevalence of parasitaemia and a survey of healthcare workers knowledge and practices in a district hospital in Ghana

April 23, 2016 - 16:16 -- Open Access
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Author(s): 
Alex Owusu-Ofori, Dominic Gadzo and Imelda Bates
Reference: 
Malaria Journal 2016 15:234, 23 April 2016

The prevalence of P. falciparum parasitaemia is 10 % in healthy blood donors in the Akatsi district and represents a risk for TTM though the extent of this risk is unclear.

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Decreased prevalence of Plasmodium falciparum resistance markers to amodiaquine despite its wide scale use as ACT partner drug in Zanzibar

September 13, 2012 - 13:22 -- Kabogo Ndegwa
Author(s): 
Fröberg G, Jörnhagen L, Morris U, Shakely D, Msellem MI, Gil JP, Björkman A, Mårtensson A
Reference: 
Malaria Journal 2012, 11:321 (11 September 2012)

MalariaWorldThis is the first observation of a decreased prevalence of pfcrt 76T, pfmdr1 86Y, 184Y and 1246Y in an African setting after several years of extensive ASAQ use as first-line treatment for uncomplicated malaria.

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NOT Open Access | Various pfcrt and pfmdr1 Genotypes of Plasmodium falciparum Cocirculate with P. malariae, P. ovale spp., and P. vivax in Northern Angola

September 13, 2012 - 12:35 -- Kabogo Ndegwa
Author(s): 
Cláudia Fançony, Dina Gamboa, Yuri Sebastião, Rachel Hallett, Colin Sutherland, José Carlos Sousa-Figueiredo, and Susana Vaz Nery
Reference: 
Antimicrob. Agents Chemother. October 2012 vol. 56 no. 10 5271-5277

MalariaWorldArtemisinin-based combination therapy for malaria has become widely available across Africa.

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NOT Open Access | Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro

August 22, 2012 - 06:43 -- Kabogo Ndegwa
Author(s): 
Fabián E. Sáenz, Tina Mutka, Kenneth Udenze, Ayoade M. J. Oduola, and Dennis E. Kyle
Reference: 
Antimicrob. Agents Chemother. September 2012 vol. 56 no. 9 4685-4692

MalariaWorldNew drugs to treat malaria must act rapidly and be highly potent against asexual blood stages, well tolerated, and affordable to residents of regions of endemicity.

NOT Open Access | Antiplasmodial potential of medicinal plant extracts from Malaiyur and Javadhu hills of South India

July 26, 2012 - 12:03 -- Kabogo Ndegwa
Author(s): 
Chinnaperumal Kamaraj, Naveen Kumar Kaushik, Dinesh Mohanakrishnan, Gandhi Elango, Asokan Bagavan, Abdul Abduz Zahir, Abdul Abdul Rahuman & Dinkar Sahal
Reference: 
Parasitology Research, Volume 111, Number 2 (2012), 703-715

In the present study, we found that 129S1 mice are resistant to the infection with Plasmodium yoelii 17XL, which is highly virulent and causes lethal infection in various strains of mice.The emergence and spread of Plasmodium falciparum with resistance to chloroquine (CQ), the safest and cheapest anti-malarial drug, coupled with the increasing cost of alternative drugs especially in developing countries have necessitated the urgent need to tap the potential of plants for novel anti-malarials.

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