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antibodies

Open Access | Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion

March 23, 2010 - 20:40 -- Ingeborg van Schayk
Author(s): 
Ute Woehlbier, Christian Epp, Fiona Hackett, Michael J Blackman, Hermann Bujard
Reference: 
Malaria Journal 2010, 9:77 (18 March 2010)

The findings reported provide further support for the development of vaccines based on MSP-1/6/7 and AMA-1, which would possibly include a combination of these antigens.

Medical Treatment: 

Open Access | Acquisition of antibodies to merozoite surface protein 3 among residents of Korogwe, north eastern Tanzania

March 17, 2010 - 09:16 -- Ingeborg van Schayk
Author(s): 
Method D Segeja, Bruno P Mmbando, Misago D Seth, John P Lusingu and Martha M Lemnge
Reference: 
BMC Infectious Diseases 2010, 10:55

This study aimed at assessing natural acquisition of antibodies to MSP3 in individuals living in an area with different malaria transmission intensity in preparation for malaria vaccine trials.

Country: 

Open Access | Mapping Epitopes of the Plasmodium vivax Duffy Binding Protein with Naturally Acquired Inhibitory Antibodies

February 26, 2010 - 17:28 -- Ingeborg van Schayk
Author(s): 
Patchanee Chootong, Francis B. Ntumngia, Kelley M. VanBuskirk, Jia Xainli, Jennifer L. Cole-Tobian, Christopher O. Campbell, Tresa S. Fraser, Christopher L. King, and John H. Adams
Reference: 
Infect. Immun. 2010;78 1089-1095

These results represent an important advance in our understanding of part of blood-stage immunity to P. vivax and some of the specific targets for vaccine-elicited antibody protection.

Technology: 

Allele-specific antibodies to Plasmodium falciparum merozoite surface protein-2 and protection against clinical malaria

February 11, 2010 - 13:41 -- Kabogo Ndegwa
Author(s): 
F. H. A. Osier, L. M. Murugi, G. Fegan, J. Tuju, K. K. Tetteth, P. C. Bull, D. J. Conway, K. Marsh
Reference: 
Parasite Immunology, Volume 32, Issue 3, Pages: 193-201

IgG and IgG3 antibodies to merozoite surface protein-2 (MSP-2) of Plasmodium falciparum have been associated with protection from clinical malaria in independent studies. We determined whether this protection was allele-specific by testing whether children who developed clinical malaria lacked IgG/IgG3 antibodies specific to the dominant msp2 parasite genotypes detected during clinical episodes. We analysed pre-existing IgG and IgG1/IgG3 antibodies to antigens representing the major dimorphic types of MSP-2 by ELISA.

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