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Open Access | Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion

March 23, 2010 - 20:40 -- Ingeborg van Schayk
Ute Woehlbier, Christian Epp, Fiona Hackett, Michael J Blackman, Hermann Bujard
Malaria Journal 2010, 9:77 (18 March 2010)

The findings reported provide further support for the development of vaccines based on MSP-1/6/7 and AMA-1, which would possibly include a combination of these antigens.

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Open Access | Acquisition of antibodies to merozoite surface protein 3 among residents of Korogwe, north eastern Tanzania

March 17, 2010 - 09:16 -- Ingeborg van Schayk
Method D Segeja, Bruno P Mmbando, Misago D Seth, John P Lusingu and Martha M Lemnge
BMC Infectious Diseases 2010, 10:55

This study aimed at assessing natural acquisition of antibodies to MSP3 in individuals living in an area with different malaria transmission intensity in preparation for malaria vaccine trials.


Open Access | Mapping Epitopes of the Plasmodium vivax Duffy Binding Protein with Naturally Acquired Inhibitory Antibodies

February 26, 2010 - 17:28 -- Ingeborg van Schayk
Patchanee Chootong, Francis B. Ntumngia, Kelley M. VanBuskirk, Jia Xainli, Jennifer L. Cole-Tobian, Christopher O. Campbell, Tresa S. Fraser, Christopher L. King, and John H. Adams
Infect. Immun. 2010;78 1089-1095

These results represent an important advance in our understanding of part of blood-stage immunity to P. vivax and some of the specific targets for vaccine-elicited antibody protection.


Allele-specific antibodies to Plasmodium falciparum merozoite surface protein-2 and protection against clinical malaria

February 11, 2010 - 13:41 -- Kabogo Ndegwa
F. H. A. Osier, L. M. Murugi, G. Fegan, J. Tuju, K. K. Tetteth, P. C. Bull, D. J. Conway, K. Marsh
Parasite Immunology, Volume 32, Issue 3, Pages: 193-201

IgG and IgG3 antibodies to merozoite surface protein-2 (MSP-2) of Plasmodium falciparum have been associated with protection from clinical malaria in independent studies. We determined whether this protection was allele-specific by testing whether children who developed clinical malaria lacked IgG/IgG3 antibodies specific to the dominant msp2 parasite genotypes detected during clinical episodes. We analysed pre-existing IgG and IgG1/IgG3 antibodies to antigens representing the major dimorphic types of MSP-2 by ELISA.


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