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antibodies

Not Open Access | Naturally acquired antibodies to Plasmodium vivax blood-stage vaccine candidates (PvMSP-119 and PvMSP-3α359−798) and their relationship with hematological features in malaria patients from the Brazilian Amazon

July 2, 2012 - 13:26 -- Patrick Sampao
Author(s): 
Luiza Carvalho Mourão, Cristiane Guimarães Morais, Érika Martins Braga, et al.
Reference: 
Microbes and Infection, Volume 14, Issue 9, August 2012, Pages 730-739

MalariaWorldWe investigated specific antibody responses against two Plasmodium vivax vaccine candidates, PvMSP-119 and PvMSP-3α359−798. Moreover, we assessed the relationship between these antibodies and morbidity parameters.

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Monoclonal Antibodies Against Recombinant Histidine-Rich Protein 2 of Plasmodium falciparum and Their Use in Malaria Diagnosis

January 19, 2012 - 15:04 -- Patrick Sampao
Author(s): 
Samuel Merwyn, Natarajan Gopalan, Anil Kumar Singh, Ganga Prasad Rai, and Gauri Shanker Agarwal.
Reference: 
Hybridoma. December 2011, 30(6): 519-524.

MalariaWorldIn this study, a set of five monoclonal antibodies against recombinant HRPII (rHRPII) were generated and assessed for their potential in diagnostics.

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A polyvalent hybrid protein elicits antibodies against the diverse allelic types of block 2 in Plasmodium falciparum merozoite surface protein 1

October 17, 2011 - 07:43 -- Patrick Sampao
Author(s): 
Kevin K.A. Tetteh, David J. Conway
Reference: 
Vaccine, Volume 29, Issue 44, 13 October 2011, Pages 7811-7817

MalariaWorldWe designed a polyvalent hybrid recombinant protein incorporating sequences of the three major allelic types of block 2 together with a composite repeat sequence of one of the types and N-terminal flanking T cell epitopes, and compared this with a series of recombinant proteins containing modular sub-components and similarly expressed in Escherichia coli.

The NTS-DBL2X Region of VAR2CSA Induces Cross-Reactive Antibodies That Inhibit Adhesion of Several Plasmodium falciparum Isolates to Chondroitin Sulfate A

September 2, 2011 - 12:19 -- Patrick Sampao
Author(s): 
Pascal Bigey, Sédami Gnidehou, Justin Doritchamou, Mickael Quiviger, Firmine Viwami, Aude Couturier, Ali Salanti, Morten A. Nielsen,Daniel Scherman, Philippe Deloron and Nicaise Tuikue Ndam
Reference: 
J Infect Dis. (2011) 204 (7): 1125-1133.

This study highlights an important step achieved toward development of a protective vaccine against placental malaria.

B cell epitope mapping and characterization of naturally acquired antibodies to the Plasmodium vivax Merozoite Surface Protein-3α (PvMSP-3α) in malaria exposed individuals from Brazilian Amazon

February 7, 2011 - 09:12 -- Patrick Sampao
Author(s): 
J.C. Lima-Junior., J. Jiang., Oliveira-Ferreira., et al
Reference: 
Vaccine, Volume 29, Issue 9, 17 February 2011, Pages 1801-1811

Our results indicates that PvMSP3 is highly immunogenic in naturally exposed populations, where 78% of studied individuals present IgG immune response against the full-length recombinant protein (PVMSP3-FL) and IgG subclass profile was similar to all five recombinant proteins studied with a high predominance of IgG1 and IgG3.

A highly sensitive solid-phase radioimmunoassay for the assay of Plasmodium falciparum antigens and antibodies

January 21, 2011 - 08:30 -- Patrick Sampao
Author(s): 
H. Avraham, J. Golenser, Y. Gazitt, D.T. Spira, D. Sulitzeanu
Reference: 
Journal of Immunological Methods, Volume 53, Issue 1, 27 August 1982, Pages 61-68

A highly sensitive radioimmunoassay for detection of P. falciparum antibodies and antigens is described.

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Open Access | Augmented plasma microparticles during acute Plasmodium vivax infection

November 24, 2010 - 07:41 -- Kabogo Ndegwa
Author(s): 
Fernanda MF Campos, Bernardo S Franklin, Andrea Teixeira-Carvalho, Agnaldo LS Filho, Salua CO de Paula, Cor J Fontes, Cristiana F Brito, Luzia H Carvalho
Reference: 
Malaria Journal 2010, 9:327 (16 November 2010)

Abundant circulating MPs are present during acute P. vivax infection, and platelet derived-MPs may play a role on the acute inflammatory symptoms of malaria vivax.

Antibodies to Chondroitin Sulfate A–Binding Infected Erythrocytes: Dynamics and Protection during Pregnancy in Women Receiving Intermittent Preventive Treatment

April 9, 2010 - 17:46 -- Ingeborg van Schayk
Author(s): 
Elizabeth H. Aitken, Bernard Mbewe, Mari Luntamo, Ken Maleta, Teija Kulmala, Marc‐James Friso, Freya J. I. Fowkes, James G. Beeson, Per Ashorn, and Stephen J. Rogerson
Reference: 
The Journal of Infectious Diseases 2010;201:1316–1325

Levels of IgG antibody to pregnancy‐specific VSAs decrease during receipt of IPTp. Antibody levels in early pregnancy did not predict clinical outcome. IPTp and decreasing malaria prevalence pose challenges for the evaluation of novel interventions for malaria during pregnancy.

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Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth

March 31, 2010 - 11:30 -- Patrick Sampao
Author(s): 
Joseph T. Bruder, Maureen E. Stefaniak, Noelle B. Patterson, Ping Chen, Svetlana Konovalova, Keith Limbach, Joseph J. Campo, Damodar Ettyreddy, Sheng Li, Filip Dubovsky, Thomas L. Richie, C. Richter King, Carole A. Long, Denise L. Doolan
Reference: 
Vaccine, Volume 28, Issue 18, 19 April 2010, Pages 3201-3210

These data highlight the importance of rational vaccine design and support the advancement of adenovector delivery technology for a malaria vaccine.

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Review: Erythrocyte invasion and functionally inhibitory antibodies in Plasmodium falciparum malaria

March 31, 2010 - 09:46 -- Patrick Sampao
Author(s): 
Kristina E.M. Persson
Reference: 
Acta Tropica, Volume 114, Issue 3, June 2010, Pages 138-143

This review gives an overview of the erythrocyte invasion process, which has been described to include several different antigens.

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