The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 11149 malaria professionals are enjoying the free benefits of MalariaWorld today

erythrocyte Invasion

Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and the Rhoptry Neck Protein Complex Defines a Key Step in the Erythrocyte Invasion Process of Malaria Parasites

May 3, 2010 - 14:12 -- Patrick Sampao
Dave R., Christopher A., et al.
The Journal of Biological Chemistry, 285, 14815-14822.

Here we show that the R1 peptide binds the PfAMA1 hydrophobic trough and demonstrate that binding to this region prevents its interaction with the PfRON complex. We show that this defined association between PfAMA1 and the PfRON complex occurs after reorientation and engagement of the actomyosin motor and argue that it precedes rhoptry release.

Open Access | Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites

February 11, 2010 - 13:53 -- Ingeborg van Schayk
Shailja Singh, M. Mahmood Alam, Ipsita Pal-Bhowmick, Joseph A. Brzostowski, Chetan E. Chitnis
PLoS Pathog 6(2): e1000746


The invasion of erythrocytes by Plasmodium merozoites requires specific interactions between host receptors and parasite ligands. We have used time-lapse video microscopy to study changes in intracellular calcium levels in Plasmodium falciparum merozoites during erythrocyte invasion.

Subscribe to RSS - erythrocyte Invasion