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erythrocyte Invasion

Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and the Rhoptry Neck Protein Complex Defines a Key Step in the Erythrocyte Invasion Process of Malaria Parasites

May 3, 2010 - 14:12 -- Patrick Sampao
Author(s): 
Dave R., Christopher A., et al.
Reference: 
The Journal of Biological Chemistry, 285, 14815-14822.

Here we show that the R1 peptide binds the PfAMA1 hydrophobic trough and demonstrate that binding to this region prevents its interaction with the PfRON complex. We show that this defined association between PfAMA1 and the PfRON complex occurs after reorientation and engagement of the actomyosin motor and argue that it precedes rhoptry release.

Open Access | Distinct External Signals Trigger Sequential Release of Apical Organelles during Erythrocyte Invasion by Malaria Parasites

February 11, 2010 - 13:53 -- Ingeborg van Schayk
Author(s): 
Shailja Singh, M. Mahmood Alam, Ipsita Pal-Bhowmick, Joseph A. Brzostowski, Chetan E. Chitnis
Reference: 
PLoS Pathog 6(2): e1000746

 

The invasion of erythrocytes by Plasmodium merozoites requires specific interactions between host receptors and parasite ligands. We have used time-lapse video microscopy to study changes in intracellular calcium levels in Plasmodium falciparum merozoites during erythrocyte invasion.

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