We discuss the implications of our results for understanding prevalence patterns in long-term malaria datasets from Kenya that show multi-annual cycles and one from Thailand that does not and discuss the possible implications of treatment.
Parasite blood-stage attenuation should help identify protective immune responses against malaria, unravel parasite-derived factors involved in malarial pathologies, such as cerebral malaria, and potentially pave the way for blood-stage whole organism vaccines.
This study reports the impact of HIV-1 infection and other variables on the level of malaria humoral immunity in adults with clinical malaria and whether humoral immune suppression was a risk factor for treatment failure.
The findings support the view that placental parasitization is significantly associated with partial maturation of different dendritic cell subsets and also to slightly increased responses to TLR9 ligand in cord blood.
Failure to distinguish between individuals who do not get a clinical episode during follow-up because they were unexposed and those who are genuinely immune undermines our ability to assign a protective role to immune responses against malaria. The brevity of antibodies responses makes it difficult to assign the true serological status of an individual at any given time, i.e. those positive at a survey may be negative by the time they encounter the next infection.